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UnknownAll-cause and disease-specific mortality in young adults with MASLD: A nationwide cohort study.

Background & aims

Metabolic dysfunction-associated steatotic liver disease (MASLD) has become a major cause of chronic liver disease globally, particularly among young adults. We aimed to analyze all-cause and disease-specific mortality in young adults with MASLD.

Methods

In this nati...
S-EPMC12355101 | biostudies-literature
UnknownDecrease of Muscle Mass in Young Patients With Neuromuscular Disease: Assessment of Sarcopenia.

Background

Sarcopenia can be associated with the disease etiologies other than degenerative processes, such as neurologic disease including cerebral palsy, myelomeningocele, or Duchenne muscular dystrophy, even in children. Although the relationship between neurologic disease and scoliosis o...
S-EPMC10226852 | biostudies-literature
UnknownConsumption of Oleic Acid During Matriphagy in Free-Living Nematodes Alleviates the Toxic Effects of the Bacterial Metabolite Violacein.
Maternal behaviors benefit the survival of young, contributing directly to the mother's reproductive fitness. An extreme form of this is seen in matriphagy, when a mother performs the ultimate sacrifice and offers her body as a meal for her young. Whether matriphagy offers only a single energy-rich ...
S-EPMC7229185 | biostudies-literature
UnknownIdentifying Target Risk Factors Using Population Attributable Risks of Ischemic Stroke by Age and Sex.

Background and purpose

Estimating age- and sex-specific population attributable risks (PARs) of major risk factors for stroke may be a useful strategy to identify risk factors for targeting preventive strategies.

Methods

For this case-control matched study, consecutive patients aged 1...
S-EPMC4635707 | biostudies-literature
UnknownRole of Serum Pepsinogen II and Helicobacter pylori Status in the Detection of Diffuse-Type Early Gastric Cancer in Young Individuals in South Korea.

Background/aims

The utility of serum pepsinogen (sPG) I and the sPGI/II ratio as biomarkers for screening individuals with gastric cancer (GC) has not been established in Korea. The aim of this study was to define the role of sPG, especially sPGII, in GC screening.

Methods

This study ...
S-EPMC7366145 | biostudies-literature
UnknownGenomic Landscape of Young-Onset Bladder Cancer and Its Prognostic Implications on Adult Bladder Cancer.
Due to the rare occurrence of young-onset bladder cancer (YBC), its genomic characteristics remain largely unknown. Twenty-nine biopsy-proven YBC cases were collected using a nation-wide search for bladder cancer diagnosed at 20 years or younger. Whole exome sequencing and RNA sequencing were carrie...
S-EPMC7073191 | biostudies-literature
UnknownRNA-Seq analysis reveals new evidence for inflammation-related changes in aged kidney.
Age-related dysregulated inflammation plays an essential role as a major risk factor underlying the pathophysiological aging process. To better understand how inflammatory processes are related to aging at the molecular level, we sequenced the transcriptome of young and aged rat kidney using RNA-Seq...
S-EPMC5058662 | biostudies-literature
UnknownAge-Related Incidence and Peak Occurrence of Contralateral Breast Cancer.

Importance

Young patients with breast cancer have higher risk for developing contralateral breast cancer (CBC) and have epidemiologic characteristics different from those of older patients.

Objective

To examine the incidence and peak occurrence of CBC according to age at primary breas...
S-EPMC10724757 | biostudies-literature
UnknownGlobal, regional, and national mortality among young people aged 10-24 years, 1950-2019: a systematic analysis for the Global Burden of Disease Study 2019.

Background

Documentation of patterns and long-term trends in mortality in young people, which reflect huge changes in demographic and social determinants of adolescent health, enables identification of global investment priorities for this age group. We aimed to analyse data on the number of...
S-EPMC8576274 | biostudies-literature
UnknownEarly Developmental Characteristics and Features of a Three-Dimensional Retinal Organoid Model of X-Linked Juvenile Retinoschisis.
X-linked juvenile retinoschisis (XLRS) is a hereditary retinal degeneration affecting young males caused by mutations in the retinoschisin (RS1) gene. We generated human induced pluripotent stem cells (hiPSCs) from XLRS patients and established three-dimensional retinal organoids (ROs) for di...
S-EPMC11311801 | biostudies-literature
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