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TranscriptomicsFunctional analysis of HOXD9 in human gliomas and glioma cancer stem cells
HOX genes encode a family of homeodomain-containing transcription factors involved in the determination of cell fate and identity during embryonic development. They also behave as oncogenes in some malignancies. In this study, we found high expression of the HOXD9 gene transcript in glioma cell line...
ORGANISM(S): Homo sapiens 
2011-04-16 | E-GEOD-28618 | biostudies-arrayexpress
MetabolomicsUnexpected similarities between the Schizosaccharomyces and human blood metabolomes, and novel human metabolites (Blood fraction)
Metabolomics, a new branch of chemical biology, provides compositional and quantitative information about the state of organism or cell at the levels of metabolite constituents. We here report non-targeted metabolome of human blood that is made up of plasma and red blood cells (RBCs), using liquid-c...
2014-07-08 | MTBLS87 | MetaboLights
TranscriptomicsImmune cells direct epithelial maturation during early human lung development
The adult human lung harbours a significant proportion of immune cells, which are known to play a crucial role in both normal lung homeostasis and pathogenesis. In this work, we collected CD45-enriched human lung cells from 6 to 22 week post conception (pcw) and built a single-cell transcriptome and...
ORGANISM(S): Homo sapiens 
2022-12-09 | E-MTAB-11528 | biostudies-arrayexpress
MetabolomicsUnexpected similarities between the Schizosaccharomyces and human blood metabolomes, and novel human metabolites (Blood plasma and RBC fractions)
Metabolomics, a new branch of chemical biology, provides compositional and quantitative information about the state of organism or cell at the levels of metabolite constituents. We here report non-targeted metabolome of human blood that is made up of plasma and red blood cells (RBCs), using liquid-c...
2014-07-08 | MTBLS88 | MetaboLights
TranscriptomicsTranscription profiling of Arabdiopsis plants over-expressing MKK3DD or MKK4DD to identify genes acting downstream of MAP kinase kinase
To identify genes acting downstream of MAP kinase kinase, and thus map its signal, we used the steroid-inducible overexpression system. The constitutive active form MKK3 (MKK3DD) or MKK4 (MKK4DD) was cloned into the glucocorticoid-inducible vector pTA7002 and transformed using Agrobacterium method i...
ORGANISM(S): Arabidopsis thaliana 
2007-05-11 | E-MEXP-827 | biostudies-arrayexpress
MetabolomicsResveratrol metabolism in HepG2 (human hepatocytes), HaCaT (human keratinocytes), and C2C12 (mouse myoblasts)
Resveratrol (RESV) is a plant polyphenol, which is thought to have beneficial metabolic effects in laboratory animals as well as in humans. Following oral administration, RESV is immediately catabolized, resulting in low bioavailability. This study compared RESV metabolites and their tissue distribu...
MTBLS127 | MetaboLights
MetabolomicsAbsorption efficiency of RESV through mouse skin using 3 bases in different tissues
Resveratrol (RESV) is a plant polyphenol, which is thought to have beneficial metabolic effects in laboratory animals as well as in humans. Following oral administration, RESV is immediately catabolized, resulting in low bioavailability. This study compared RESV metabolites and their tissue distribu...
2014-12-15 | MTBLS126 | MetaboLights
MetabolomicsDistribution of RESV and its metabolite peaks in mouse tissues after oral and skin administration
Resveratrol (RESV) is a plant polyphenol, which is thought to have beneficial metabolic effects in laboratory animals as well as in humans. Following oral administration, RESV is immediately catabolized, resulting in low bioavailability. This study compared RESV metabolites and their tissue distribu...
2014-12-15 | MTBLS125 | MetaboLights
TranscriptomicsA high-resolution single-cell multiomic atlas of the human fetal lung - Organoid
Individual TFs were overexpressed in fetal lung tip organoids from a doxycycline-inducible construct for 3 days, and organoids were maintained in the self-renewing (tip cell-promoting) medium throughout to rigorously assay the lineage-determining competence of the TF, followed by scRNA-seq. ASCL1, ...
ORGANISM(S): Homo sapiens 
2022-01-27 | E-MTAB-11267 | biostudies-arrayexpress
TranscriptomicsA high-resolution single-cell multiomic atlas of the human fetal lung - Visium
Fetal lung samples at 12–20 post conception week (pcw) from the HDBR, up to 0.5cm3 in size, were embedded in OCT and flash-frozen in dry-ice cooled isopentane. Twelve-micron cryosections were cut onto Visium slides, haematoxylin and eosin stained and imaged at 20X magnification on a Hamamatsu Nanozo...
ORGANISM(S): Homo sapiens 
2022-01-27 | E-MTAB-11265 | biostudies-arrayexpress
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