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GenomicsPromoter Decommissioning by the NuRD Chromatin Remodeling Complex Triggers Synaptic Connectivity in the Mammalian Brain
Precise control of gene expression plays fundamental roles in brain development, but the roles of chromatin regulators in neuronal connectivity have remained poorly understood. Here, we find that depletion of the nucleosome remodeling and deacetylation (NuRD) complex in the cerebellar cortex by in v...
ORGANISM(S): Mus musculus 
2014-08-18 | E-GEOD-57758 | biostudies-arrayexpress
TranscriptomicsIkaros mutation confers integrin-dependent pre-B cell survival and progression to acute lymphoblastic leukemia
Deletion of the Ikaros DNA-binding domain generates dominant-negative isoforms that interfere with Ikaros family activity and correlate with poor prognosis in human precursor B cell acute lymphoblastic leukemias (B-ALL).  Here, we show that conditional inactivation of the Ikaros DNA binding domain i...
ORGANISM(S): Mus musculus 
2014-02-09 | E-GEOD-53401 | biostudies-arrayexpress
TranscriptomicsHarnessing of the Nucleosome Remodeling Deacetylase complex controls lymphocyte development and prevents leukemogenesis
Cell fate decisions depend on the interplay between chromatin regulators and transcription factors. Here we show that activity of the Mi-2u Nucleosome Remodeling and Deacetylase (NuRD) complex is controlled by the Ikaros family of lymphoid-lineage determining proteins. Ikaros, an integral component ...
ORGANISM(S): Mus musculus 
2011-11-13 | E-GEOD-32311 | biostudies-arrayexpress
UnknownBST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities.
Not available
S-EPMC8604996 | biostudies-literature
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