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TranscriptomicsInfectious Bursal Disease Virus (IBDV) Infection
Infectious bursal disease virus (IBDV) is a highly contagious dsRNA virus (Birnaviridae) which causes immuno-suppression in chickens. Although largely controlled by vaccination, new, virulent strains of the virus mean that infectious bursal disease (IBD or ëGumboroí disease) still remains a threat t...
ORGANISM(S): Gallus gallus 
2014-12-30 | E-TABM-1129 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse cerebella from pups exposed to PTU to induce hypothyroidism
Pregnant dams were treated with 0.1% or 0.04% 6-propyl-2-thiouracil (PTU) in drinking water continuously from day 13 post conception until weaning to produce hypothyroid pups. Cerebella were collected from vehicle and 0.1% PTU treated pups at post-natal day (PND) 15 and mRNA from these was subjected...
ORGANISM(S): Mus musculus 
2008-05-02 | E-MEXP-1048 | biostudies-arrayexpress
Transcriptomics90 min Met4 hyperactivation ChIP-chip
Identification of in vivo binding targets of Met4 and Met32 by conducting chromatin immunoprecipitation studies using genomic tiling arrays (ChIP-on-chip 4X44K whole yeast genome arrays by Agilent) following 90 minutes Met4 hyperactivation.
ORGANISM(S): Saccharomyces cerevisiae 
2012-02-21 | E-MEXP-3302 | biostudies-arrayexpress
TranscriptomicsTranscription profiling time series of chicken cell culturs infected with Chicken Anaemia Virus CAV
Chicken anaemia virus (CAV) causes severe anaemia and immunosuppression in young chickens. Such effects reduce the efficiency of routine vaccinations while aggravating the effects of other pathogens in chicken populations. So far, the host responses to CAV have not been studied in vivo or in vitro o...
ORGANISM(S): Gallus gallus 
2009-08-20 | E-MEXP-1229 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of responses to TNF-alpha, IL-1beta, peptidoglycan or lipopolysaccharide (TLR2/4 agonists) evaluated at 4 hrs in peripheral blood monocytes (PBM) from the patient bearing the IRAK4 Q293X mutation vs PBM from 5 healthy individuals
IL-1R associated kinase-4 (IRAK4) is a key enzyme required for activation of the common Toll-like Receptor (TLR) signaling cascade, which results in the transcription of inflammatory and immunity genes. IRAK-4 deficiency has recently been described as a rare form of innate immunodeficiency. Patien...
ORGANISM(S): Homo sapiens 
2010-05-19 | E-FPMI-7 | biostudies-arrayexpress
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