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MetabolomicsPostprandial Metabolism is Impaired in Overweight Normoglycemic Young Adults without Family History of Diabetes

While the risk factors for Type 2 diabetes (T2DM) are known, early predictive markers of transition from normal to a prediabetes state are unidentified. We studied the basal metabolism and metabolic response to a mixed-meal challenge in 110 healthy subjects in the age group of 18 to 40 years (Mal...

2019-03-14 | MTBLS743 | MetaboLights
MetabolomicsAcute response to a high-saturated, high-refined carbohydrate meal in healthy young men shows novel perturbation of multiple metabolic and defense pathways

Regular consumption of fat and refined carbohydrates induces metabolic stress, increasing chronic metabolic disease risk. In healthy volunteers, we characterised the response to a high-fat/high-carbohydrate meal (HFHCM), typical of an ultra-processed food, by proteomic and metabolomics analyses, ...

2026-04-02 | MTBLS10972 | MetaboLights
Metabolomics13C glucose labelling studies using 2D NMR is a useful tool for determining ex vivo whole organ metabolism during hypothermic machine perfusion of kidneys
Background: The aim of this study is to determine the feasibility of using Nuclear Magnetic Resonance (NMR) tracer studies (13C-enriched glucose) to detect ex vivo de novo metabolism in the perfusion fluid and cortical tissue of porcine kidneys during hypothermic machine perfusion (HMP). Methods: Po...
2017-10-16 | MTBLS367 | MetaboLights
UnknownDecreased telomere length in a subgroup of young individuals with bipolar disorders: replication in the FACE-BD cohort and association with the shelterin component POT1.
Not available
S-EPMC10907586 | biostudies-literature
TranscriptomicsDifferences in genome-wide gene expression response in PBMCs between young and old men upon caloric restriction
Caloric restriction (CR) is considered to increase lifespan and to prevent various age-related diseases in different non-human organisms. Only a limited number of CR studies have been performed in humans, and results put CR as a beneficial tool to decrease risk factors in several age-related disease...
ORGANISM(S): Homo sapiens 
2016-10-24 | E-GEOD-63117 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of Influenza vaccine response in Young and Old - Year 1
We profiled gene expression from a stratified cohort of subjects to define influenza vaccine response in Young and Old Differential gene expression by human PBMCs from Healthy Adults receiving Influenza Vaccination (Fluvirin, Novartis). Healthy adults (older >65, younger 21-30 years) were recruited ...
ORGANISM(S): Homo sapiens 
2015-01-26 | E-GEOD-59635 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of Influenza vaccine response in Young and Old - Year 2
We profiled gene expression from a stratified cohort of subjects to define influenza vaccine response in Young and Old Differential gene expression by human PBMCs from Healthy Adults receiving Influenza Vaccination (Fluvirin, Novartis). Healthy adults (older >65, younger 21-30 years) were recruited ...
ORGANISM(S): Homo sapiens 
2015-01-26 | E-GEOD-59654 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA sequencing of peripheral blood immune cells in type 2 diabetes
Single-cell RNA sequencing of peripheral blood immune cells from individuals who were apparently healthy or had type 2 diabetes (T2D), generated to test whether the circulating immune compartment is transcriptionally altered in T2D. Peripheral blood leukocytes from two healthy and two T2D donors wer...
ORGANISM(S): Homo sapiens 
2026-10-01 | E-MTAB-17317 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of CD8 T cell subsets from healthy young and elderly persons
We isolated highly purified CD8+CD28+ and CD8+CD28- T cell populations from healthy young and elderly persons for gene expression profiling using Affymetrix oligonucleotide microarrays. We demonstrate that the gene expression profile of CD8+CD28- T cells is very similar in young and elderly persons....
ORGANISM(S): Homo sapiens 
2010-09-03 | E-MEXP-2345 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of murine thymocytes reveals age-associated changes in thymic gene expression
The decline in adaptive immunity, naïve T-cell output and a contraction in the peripheral T cell receptor (TCR) repertoire with age are largely attributable to thymic involution and the loss of critical cytokines and hormones within the thymic microenvironment. To assess the molecular changes associ...
ORGANISM(S): Mus musculus 
2009-05-05 | E-GEOD-15945 | biostudies-arrayexpress
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