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TranscriptomicsTranscription profiling of skeletal muscles from young, old, and old calorie restricted C57BL/6NHsd mice to investigate age-related changes in the transcriptional profile
We investigated age-related changes in the transcriptional profile of skeletal muscle in 5 month old (young) and 25 month old (old) C57BL/6NHsd mice using high density oligonucleotide arrays (22,690 transcripts probed). We identified 712 transcripts that are differentially expressed in young (5 mon...
ORGANISM(S): Mus musculus 
2007-11-13 | E-GEOD-6323 | biostudies-arrayexpress
ProteomicsA Quantitative Yeast Aging Proteomics Analysis Reveals Novel Aging Regulators
Extending lifespan from yeast to mammals, calorie restriction (CR) is the most conserved longevity intervention. Numerous conserved pathways regulating aging and mediating CR have been identified; however, the overall proteomic changes during these conditions remain largely unexplored. We compared p...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-02-15 | PXD018917 | Pride
Yeast Aging Caloric restriction Proteome Replicative aging 
TranscriptomicsGene expression profile from short-term caloric restriction in mouse adipose tissue
To provide a robust understanding of a transcriptomic change by short-term CR at body fat of mice, we applied three serial strengths of CR to mice including 15%, 30%, and 45% reduction of carbon source. Using Affymetrix mouse 1.0 ST array platform, we obtained and analyzed the transcriptome data for...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-60596 | biostudies-arrayexpress
TranscriptomicsscATAC-seq of mouse liver tissue derived from young and old mice
We investigate if the differences in phenotype and transcriptome over age might be explained by an underlying change on the epigenetic level. We performed single-cell ATAC sequencing using the 10x Chromium platform. We profiled 4838 nuclei prepared from 3 young liver tissues and 3361 nuclei from 3 o...
ORGANISM(S): Mus musculus 
2023-02-20 | E-MTAB-12706 | biostudies-arrayexpress
TranscriptomicsComparative analyses of chromosome alterations in metastases in castration-resistant prostate cancer patients
Androgen deprivation is the mainstay of therapy for progressive prostate cancer. Despite initial and dramatic tumor inhibition, most men eventually fail therapy and die of metastatic castration-resistant (CR) disease. Here, we characterize the profound degree of genomic alteration found in CR tumors...
ORGANISM(S): Homo sapiens 
2010-05-22 | E-GEOD-18259 | biostudies-arrayexpress
TranscriptomicsTranscriptional response of durum wheat roots and leaves to continuous chromium stress
Chromium (Cr) is a highly toxic heavy metal for both mono and dicot plants, causing severe cellular damage and disturbances in plant growth, development, and reproduction. Its phytotoxicity results in serious changes in plant physiology, gene expression, and at a transgenerational level in genomic D...
ORGANISM(S): Triticum turgidum subsp. durum 
2024-08-26 | E-MTAB-13952 | biostudies-arrayexpress
GenomicsChIPseq examination of EAP-1 binding across generations of spr-5(by101) mutant worms
How epigenetic information is transmitted from generation to generation remains largely unknown. Deletion of the C. elegans Histone H3 lysine 4 dimethyl (H3K4me2) demethylase spr-5 leads to inherited accumulation of the euchromatic H3K4me2 mark and progressive decline in fertility. Here we identifie...
ORGANISM(S): Caenorhabditis elegans 
2014-04-08 | E-GEOD-52102 | biostudies-arrayexpress
UnknownTissue specific and non-specific changes in gene expression by aging and by early stage CR.
Not available
S-EPMC1764499 | biostudies-literature
TranscriptomicsscATAC-seq of mouse liver tissue derived from young and old mice II
We investigate if the differences in phenotype and transcriptome over age might be explained by an underlying change on the epigenetic level. We performed single-cell ATAC sequencing using the 10x Chromium platform. We profiled 2259 nuclei prepared from 3 young liver tissues and 2490 nuclei from 3 o...
ORGANISM(S): Mus musculus 
2023-11-09 | E-MTAB-12560 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of C. elegans exposed to quercetin and tannic acid
Recent research has highlighted that the polyphenols Quercetin (Q) and Tannic acid (TA) are capable of extending the lifespan of C. elegans. To gain a deep understanding of the underlying molecular genetics, we analyzed the global transcriptional patterns of nematodes exposed to Quercetin or Tannic ...
ORGANISM(S): Caenorhabditis elegans 
2012-02-03 | E-GEOD-35354 | biostudies-arrayexpress
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