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MetabolomicsFaecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients

BACKGROUND: The gut-brain axis and the intestinal microbiota are emerging as key players in health and disease. Shifts in intestinal microbiota composition affect a variety of systems, however, evidence of their direct impact on cognitive functions is still lacking. We tested whe...

2021-12-17 | MTBLS1437 | MetaboLights
TranscriptomicsYoung Adult reference tiling array
modENCODE_submission_656 This submission comes from a modENCODE project of Robert Waterston. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: Our experiments are designed to detect all C. elegans transcripts by hybridizing RNA to commerically available genome til...
ORGANISM(S): Caenorhabditis elegans 
2010-08-04 | E-GEOD-23280 | biostudies-arrayexpress
TranscriptomicsYoung Adult Cephalic sheath (CEPsh) tiling array
modENCODE_submission_660 This submission comes from a modENCODE project of Robert Waterston. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: Our experiments are designed to detect all C. elegans transcripts by hybridizing RNA to commerically available genome til...
ORGANISM(S): Caenorhabditis elegans 
2010-08-04 | E-GEOD-23284 | biostudies-arrayexpress
TranscriptomicsThe complex interplay of genetic pathways in C.elegans following the treatment with humic substances
Low concentrations of the dissolved leonardite humic acid HuminFeed® (HF) prolonged the lifespan and enhanced the thermal stress resistance of the model organism Caenorhabditis elegans. Furthermore growth was impaired and reproduction delayed, effects which have also been identified in other polyphe...
ORGANISM(S): Caenorhabditis elegans 
2012-02-03 | E-GEOD-35360 | biostudies-arrayexpress
UnknownHormone response element binding proteins: novel regulators of vitamin D and estrogen signaling.
Not available
S-EPMC3042887 | biostudies-literature
TranscriptomicsTranscription profiling of rat young and aged mesenchymal stem cells response to dexamethasone
To explore the molecular events that underline skeletal physiology during aging we catalogued the profile of gene expression in ex vivo cultured MSCs derived from 3 and 15 month old rats and challenged with dexamethasone (Dex). RNA retrieved from these cells was analyzed using Affymetrix Gene Chips ...
ORGANISM(S): Rattus norvegicus 
2008-06-12 | E-GEOD-3339 | biostudies-arrayexpress
MetabolomicsDiel metabolomics analysis of a hot spring chlorophototrophic microbial mat leads to new hypotheses of community member metabolisms
Dynamic environmental factors such as light, nutrients, salt, and temperature continuously affect chlorophototrophic microbial mats, requiring adaptive and acclimative responses to stabilize composition and function. Quantitative metabolomics analysis can provide insights into metabolite dynamics fo...
2024-02-23 | MTBLS187 | MetaboLights
TranscriptomicsTranscription profiling of rat Postnatal developmental changes in Sprague-Dawley animals in the model of neuropathic pain - spare nerve injury
Neuropathic pain is an apparently spontaneous experience triggered by abnormal physiology of the peripheral or central nervous system, which evolves with time. Neuropathic pain arising from peripheral nerve injury is characterized by a combination of spontaneous pain, hyperalgesia and allodynia. The...
ORGANISM(S): Rattus norvegicus 
2010-01-30 | E-GEOD-15041 | biostudies-arrayexpress
ProteomicsRaw dataset of seminal plasma proteomic of nellore bulls
These data show the proteomic profile of the seminal plasma of young Nelore bulls with an average age of 21.7 months and the genetic ontology of the identified proteins.
ORGANISM(S): Cellular Organisms 
2024-01-29 | PXD048943 | JPOST Repository
ProteomicsYoung and aged T cells LC-MS/MS
Naïve T cells (CD4+CD62LhiCD44loCD25-) were purified from spleens of young (2 months; n=3) and aged (22 months; n=3 pools of five mice) mice and were either frozen or activated for 24 hrs.
ORGANISM(S): Mus musculus (Mouse) 
2025-10-08 | PXD067102 | Pride
Heme Aging Mouse Lymph nodes Spleen 
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