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ProteomicsTMT isobaric profiling of young versus old haematopoietic stem cells
Mass spectrometry was performed with an Orbitrap Fusion Tribrid mass spectrometer (Thermo Scientific) interfaced with an UltiMate 3000 Binary RSLCnano System (Dionex). Proteome Discoverer v.1.4 (Thermo Scientific) with SEQUEST HT search engines was used for the spectra-preprocessing and HCD MS2 spec...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-10-16 | MSV000093126 | MassIVE
TranscriptomicsTranscription profiling of rat young and aged mesenchymal stem cells response to dexamethasone
To explore the molecular events that underline skeletal physiology during aging we catalogued the profile of gene expression in ex vivo cultured MSCs derived from 3 and 15 month old rats and challenged with dexamethasone (Dex). RNA retrieved from these cells was analyzed using Affymetrix Gene Chips ...
ORGANISM(S): Rattus norvegicus 
2008-06-12 | E-GEOD-3339 | biostudies-arrayexpress
TranscriptomicsGenome-wide polysome analysis in poly(I:C)-treated WT and Oasl1-/- BMDM.
OASL1 is a novel translation inhibitor for the type I IFN master transcription factor IRF7. To examine whether OASL1 specifically inhibit IRF7 translation, we used a genome-wide gene expression microarray to screen for the polysome-associated mRNAs more enriched in the OASL1 KO BMDMs. The microarray...
ORGANISM(S): Mus musculus 
2013-02-17 | E-GEOD-41787 | biostudies-arrayexpress
TranscriptomicsExpression data from the comparison between poly(I:C)-treated WT and Oasl1-/- BMDMs
Oasl1-/- BMDMs express more type I IFN upon poly(I:C) treatment. Because OASL1 seems to rather specifically suppress the type I IFN expression, we tried to address the specificity by determining the defects associated with the Oasl1 mutation using genome-wide gene expression microarray analysis unde...
ORGANISM(S): Mus musculus 
2013-02-17 | E-GEOD-41788 | biostudies-arrayexpress
TranscriptomicsCorrelates of chronic stress and their influence on the development of substance use in a population-based cohort of young adults (OYSUP)
Background: We seek to understand correlates of chronic stress and their influence on the development of substance use in a population-based cohort of young adults (OYSUP). Methodology: We evaluated clinical features, salivary RNA metrics and differential expression of candidate genes in unfraction...
ORGANISM(S): Homo sapiens 
2012-06-15 | E-GEOD-27144 | biostudies-arrayexpress
UnknownPredictors of Past-Year Health Care Utilization Among Young Men Who Have Sex with Men Using Andersen's Behavioral Model of Health Service Use.
Not available
S-EPMC9587774 | biostudies-literature
TranscriptomicsComparative genomic hybridization of high grade gliomas arising in children and young people
As genome-scale technologies begin to unravel the complexity of the equivalent tumours in adults, detailed characterisation of high grade gliomas in children have until recently been lacking. In order to validate and extend investigations of the differences between paediatric and adult tumours, we c...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-TABM-857 | biostudies-arrayexpress
UnknownClinical application of genomic profiling to find druggable targets for adolescent and young adult (AYA) cancer patients with metastasis.
Not available
S-EPMC4772349 | biostudies-literature
TranscriptomicsTranscription profiling of rat Postnatal developmental changes in Sprague-Dawley animals in the model of neuropathic pain - spare nerve injury
Neuropathic pain is an apparently spontaneous experience triggered by abnormal physiology of the peripheral or central nervous system, which evolves with time. Neuropathic pain arising from peripheral nerve injury is characterized by a combination of spontaneous pain, hyperalgesia and allodynia. The...
ORGANISM(S): Rattus norvegicus 
2010-01-30 | E-GEOD-15041 | biostudies-arrayexpress
MetabolomicsDiel metabolomics analysis of a hot spring chlorophototrophic microbial mat leads to new hypotheses of community member metabolisms
Dynamic environmental factors such as light, nutrients, salt, and temperature continuously affect chlorophototrophic microbial mats, requiring adaptive and acclimative responses to stabilize composition and function. Quantitative metabolomics analysis can provide insights into metabolite dynamics fo...
2024-02-23 | MTBLS187 | MetaboLights
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