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TranscriptomicsTranscription profiling of mouse long term HSC from control or Pbx1-null mice
Self-renewal is a defining characteristic of stem cells, however the molecular pathways underlying its regulation are poorly understood. Here we demonstrate that conditional inactivation of the Pbx1 proto-oncogene in the hematopoietic compartment results in a progressive loss of long-term hematopoi...
ORGANISM(S): Mus musculus 
2008-06-20 | E-GEOD-9188 | biostudies-arrayexpress
UnknownRadiological clinical trials: Proposal of a problem-finding questionnaire to improve study success.
Not available
S-EPMC5183990 | biostudies-literature
MetabolomicsTwo apples a day modulate human:microbiome co-metabolic processing of polyphenols, tyrosine and tryptophan

PURPOSE: Validated biomarkers of food intake (BFIs) have recently been suggested as a useful tool to assess adherence to dietary guidelines or compliance in human dietary interventions. Although many new candidate biomarkers have emerged in the last decades for different foods fr...

2020-04-28 | MTBLS469 | MetaboLights
UnknownSynergistic effect of interleukin-10-receptor variants in a case of early-onset ulcerative colitis.
Not available
S-EPMC3870512 | biostudies-literature
MetabolomicsCreation and Characterization of a Genomically Hybrid Strain in the Nitrogen-Fixing Symbiotic Bacterium Sinorhizobium meliloti
Many bacteria, often associated with eukaryotic hosts and of relevance for biotechnological applications, harbor a multipartite genome composed of more than one replicon. Biotechnologically relevant phenotypes are often encoded by genes residing on the secondary replicons. A synthetic biology approa...
2021-03-17 | MTBLS576 | MetaboLights
ProteomicsFibro-adipogenic progenitors of dystrophic mice are insensitive to NOTCH regulation of adipogenesis
Fibro adipogenic progenitors (FAPs) promote satellite cell differentiation in adult skeletal muscle regeneration. However, in pathological conditions, FAPs are responsible for fibrosis and fatty infiltrations. Here we show that the NOTCH pathway negatively modulates FAP differentiation both in vitro...
ORGANISM(S): Mus musculus (Mouse) 
2019-06-24 | PXD014195 | Pride
Adipogenesis Notch Inflammation Muscular dystrophy Myopathies Skeletal muscle regeneration Mass cytometry Fibro adipogenic progenitors Proteome 
ProteomicsProteomic quantification of native and ECM-enriched mouse ovaries reveals an age-dependent fibro-inflammatory signature
The ovarian microenvironment becomes fibrotic and stiff with age due in part to increased stromal collagen and decreased hyaluronan. However, the extracellular matrix (ECM) is a complex network of hundreds of proteins, glycoproteins and glycans which are highly tissue specific and undergo pronounced...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-04-24 | MSV000091790 | MassIVE
TranscriptomicsmicroRNA and aging
The critical role of the endothelium in governing vascular, tissues homeostasis and pathological processes is increasingly recognized (Deanfield et al., 2007). Cellular senescence of endothelial cells has been proposed to be involved in endothelial dysfunction and atherogenesis (Minamino T et al., 2...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-14912 | biostudies-arrayexpress
Other,MultiomicsUpload negative ionisation mode fragmentation data of clinical cohort from MS2LDA+ paper
Human urine samples measured using pHILIC LC-MS/MS and LC-MS in negative ionisation mode. Urine samples were from clinical cohort in which we expected to find substantial amounts of xenobiotics. Samples were used for MS2LDA substructure discovery to find the building blocks of metabolomics.
ORGANISM(S): Homo Sapiens 
2019-03-05 | MSV000083527 | MassIVE
Other,MultiomicsUpload positive ionisation mode fragmentation data of clinical cohort from MS2LDA+ paper
Human urine samples measured using pHILIC LC-MS/MS and LC-MS in positive ionisation mode. Urine samples were from clinical cohort in which we expected to find substantial amounts of xenobiotics. Samples were used for MS2LDA substructure discovery to find the building blocks of metabolomics.
ORGANISM(S): Homo Sapiens 
2019-03-05 | MSV000083526 | MassIVE
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