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ProteomicsLabel-free quantitative (LFQ) proteomic analysis of redox mediated posttranslational modifications (PTM) in the cartilage from young and old osteoarthritis (OA) mice with or without the senolytic treatment
Senolytic drugs are designed to selectively clear senescent cells (SnCs) that accumulate with injury or aging. In a mouse model of osteoarthritis (OA), senolysis yields a pro-regenerative response. However, recent research studies showed that the therapeutic benefit is reduced in aged mice. Increase...
ORGANISM(S): Mus musculus (Mouse) 
2023-09-26 | PXD031782 | Pride
Mouse model of osteoarthritis (oa)  senolytic treatment  label-free quantitative (lfq) proteomic  analysis of redox ptms in the cartilage proteins 
TranscriptomicsTranscription profiling of liver, lung, spleen and kidney from young (13 week) and aged (130 week) wild type mice
We compared the complete mouse liver, spleen, lung and kidney transcriptome of adult 13- and 130-wk old wt C57Bl/6J mice (n=3) to develop gene sets for young adult and aged wt mice, respectively
ORGANISM(S): Mus musculus 
2008-06-01 | E-MEXP-1504 | biostudies-arrayexpress
UnknownThe multiple shark Ig H chain genes rearrange and hypermutate autonomously.
Not available
S-EPMC3190574 | biostudies-literature
TranscriptomicsExposure to Propylthiouracil in Pregnant Mice Potentiates the Transcriptional Response to Thyroid Hormone in the Fetal Cerebral Cortex
Although the effects of thyroid hormones (TH) on the brain development have been extensively studied perinatally, effects of TH of maternal origin on the fetal brain development have been largely unexplored. We applied a high throughput study on the mouse models with aberrant TH levels on gestation ...
ORGANISM(S): Mus musculus 
2014-02-04 | E-GEOD-43927 | biostudies-arrayexpress
UnknownSleep EEG in young people with 22q11.2 deletion syndrome: A cross-sectional study of slow-waves, spindles and correlations with memory and neurodevelopmental symptoms.
Not available
S-EPMC9477499 | biostudies-literature
UnknownComparison of repeated toxicity of polyhexamethyleneguanidine phosphate, a causative agent of humidifier disinfectant tragedy, in young and adult mice.
Not available
S-EPMC11502745 | biostudies-literature
MetabolomicsHuman Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice
Autism spectrum disorder (ASD) manifests as alterations in complex human behaviors including social communication and stereotypies. In addition to genetic risks, the gut microbiome differs between typically-developing (TD) and ASD individuals, though it remains unclear whether the microbiome contrib...
2019-07-04 | MTBLS726 | MetaboLights
UnknownComplete genome sequences of five Ackermannviridae that infect Enterobacteriaceae hosts.
Not available
S-EPMC10927658 | biostudies-literature
UnknownIntegrated Transcriptomic and Metabolomic Analysis Reveals <i>VASH1</i> Influences Pork Quality by Regulating Skeletal Muscle Glycolysis.
Not available
S-EPMC12651661 | biostudies-literature
UnknownReturn to Work After Acute Myocardial Infarction: Comparison Between Young Women and Men.
Not available
S-EPMC4771977 | biostudies-literature
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