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TranscriptomicsTranscription profiling of human node-negative breast cancer patients to validate a 70-gene prognostic signature on a high-throughput microarray
A 70-gene signature has been shown to be a powerful predictor of disease outcome in young breast cancer patients. The microarrays were not designed for high throughput processing. To facilitate the use in a diagnostic setting, the profile was translated into a customized microarray containing a redu...
ORGANISM(S): Homo sapiens 
2007-02-23 | E-TABM-115 | biostudies-arrayexpress
ProteomicsNAD Depletion in Skeletal Muscle does not Compromise Muscle Function or Accelerate Aging
NAD is a ubiquitous electron carrier essential for energy metabolism and the post translational modification of numerous regulatory proteins. Perturbation of NAD metabolism is considered detrimental to health, with NAD depletion commonly thought to promote aging. However, the extent to which cellula...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-23 | PXD061221 | Pride
Nad metabolism  nampt  skeletal muscle  aging  exercise  mitochondrial supercomplexes 
TranscriptomicsGenome wide expression in liver of young adult (D90) and aged (D456) female C57/BL6 mice in F1 and F3 generations.
Analysis of the effect of diet and ageing in the liver at gene expression level. The hypothesis tested in the present study was that dietary energy would be associated positively with the magnitude of age-related changes in the expression of the liver transcriptome and that such effects would accumu...
ORGANISM(S): Mus musculus 
2015-07-24 | E-GEOD-71246 | biostudies-arrayexpress
GenomicsHoxC11 ChIP-seq of LY2 Breast Cancer Cell Line
SRC-1 (NCOA1) is a steroid receptor coactivator that has been associated with various aspects of the progression of breast cancer disease such as tamoxifen resistance, metastasis, cell proliferation and invasiveness. In a tamoxifen resistant breast cancer cell line (LY2), SRC-1 has been found to in...
ORGANISM(S): Homo sapiens 
2014-01-14 | E-GEOD-54027 | biostudies-arrayexpress
GenomicsGenome wide association study on coronary heart disease in patients with familial hypercholesterolemia
Mutations in the low-density lipoprotein receptor (LDLR) gene cause familial hypercholesterolemia (FH), a disorder characterized by coronary heart disease (CHD) at young age. We aimed to apply an extreme sampling method to enhance the statistical power to identify novel genetic risk variants for CHD...
EGAS00001000734 | EGA
TranscriptomicsTranscriptomic profiling of sequential tumours from breast cancer patients provides a global view of metastatic expression changes following endocrine therapy
We profiled primary breast cancer, nodal and liver metastatic tumours from three patients. At the time of initial diagnosis, all three patients presented with luminal breast cancer with adjacent nodal metastasis. They all received 5 years of enodrine therapy and all subsequently developed liver meta...
ORGANISM(S): Homo sapiens 
2015-10-28 | E-GEOD-58708 | biostudies-arrayexpress
TranscriptomicsSRC1 gene regulation in endocrine resistant breast cancer cells
The development of breast cancer resistance to endocrine therapy results from an increase in cellular plasticity leading to the development of a steroid independent tumour. The p160 steroid coactivator protein SRC-1, through interactions with developmental proteins and other non-steroidal transcrip...
ORGANISM(S): Homo sapiens 
2012-01-11 | E-GEOD-28645 | biostudies-arrayexpress
GenomicsErasmus MC - ARGOS study Data Access Committee
Data Access Committee EGAC00001000182
EGAC00001000182 | EGA
GenomicsFH+CAD - samples
Gencode case samples using 550K
EGAD00010000578 | EGA
GenomicsFH+Controls - samples
Gencode control samples using 550K
EGAD00010000580 | EGA
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