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TranscriptomicsInterrogation of global mutagenesis data with a genome scale model of Neisseria meningitidis to assess gene fitness in vitro and in sera.
Background Neisseria meningitidis is an important human commensal and pathogen that causes several thousand deaths each year, mostly in young children. How the pathogen replicates and causes disease in the host is largely unknown, particularly the role of metabolism in colonization and disease. Com...
ORGANISM(S): Neisseria meningitidis 
2012-01-23 | E-BUGS-129 | biostudies-arrayexpress
GenomicsIdentification of Transcription Factor N2::POL II Binding Regions in Young Adult
modENCODE_submission_2441 This submission comes from a modENCODE project of Michael Snyder. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: We are identifying the DNA binding sites for 300 transcription factors in C. elegans. Each transcription factor gene is ta...
ORGANISM(S): Caenorhabditis elegans 
2011-02-18 | E-GEOD-25794 | biostudies-arrayexpress
GenomicsTDP-1, the C. elegans ortholog of TDP-43, limits the accumulation of double stranded RNA
C. elegans mutants deleted for TDP-1, an ortholog of the neurodegeneration-associated RNA binding protein TDP-43, display only mild phenotypes. Nevertheless, transcriptome sequencing revealed that many RNAs were altered in accumulation and/or processing in the mutant. Analysis of these transcription...
ORGANISM(S): Caenorhabditis elegans 
2014-11-19 | E-GEOD-61581 | biostudies-arrayexpress
TranscriptomicsRNA-seq for gastric cancer and normal tissues/cells
We performed RNA-seq experiments to identify differentially expressed intergenic transcripts between gastric cancer and normal tissues/cells. Three primary cell culture samples from gastric cancer tissues, three gastric cancer cell lines and two normal tissue samples were used for the experiments.
ORGANISM(S): Homo sapiens 
2013-10-10 | E-GEOD-41476 | biostudies-arrayexpress
UnknownModulation of Milk Allergenicity by Baking Milk in Foods: A Proteomic Investigation.
Not available
S-EPMC6683078 | biostudies-literature
UnknownEnterovirus 71 infection causes severe pulmonary lesions in gerbils, meriones unguiculatus, which can be prevented by passive immunization with specific antisera.
Not available
S-EPMC4359154 | biostudies-literature
TranscriptomicsTranscription profiling of C. elegans treated with oxidative stress vs. controls
Oxidative stress may play a role in normal aging. SKN-1 is a transcription factor necessary for intestine development in Caenorhabditis elegans, which also regulates the response to oxidative stress post-embryonically. Using DNA microarrays, we found that oxidative stress induces the antioxidant res...
ORGANISM(S): Caenorhabditis elegans 
2008-06-16 | E-GEOD-9301 | biostudies-arrayexpress
UnknownDetection of Serum Cross-Reactive Antibodies and Memory Response to SARS-CoV-2 in Prepandemic and Post-COVID-19 Convalescent Samples.
Not available
S-EPMC8557674 | biostudies-literature
TranscriptomicsSema4A, a novel serum marker of multiple sclerosis, implicates Th17 pathology and efficacy of interferon-β.
Background: Multiple sclerosis (MS) is a demyelinating autoimmune disease of the central nervous system and the leading cause of lasting neurological disabilities in young adults. Increasing evidence suggests that early treatment prevents the development of disability. However, there have been no re...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-26484 | biostudies-arrayexpress
TranscriptomicsTransforming growth factor-B1 drives differentiation of the embryonic jejunum
Transcription profiling by microarray was performed to pinpoint the roles of transforming growth factor B1 (TGFB1) in embryonic differentiation of the small intestine. An organ culture system in which mouse jejunal rudiments were placed on semipermeable platforms and fed with chemically defined seru...
ORGANISM(S): Mus musculus 
2017-04-03 | E-MTAB-4509 | biostudies-arrayexpress
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