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TranscriptomicsRNAseq of young adult C. elegans animals fed on three different bacterial diets, E. coli OP50, B. subtilis PXN21 and a mixture of both
To uncover the host response pathways that are modified by a B. subtilis diet and that may provide the protective effect against α-synuclein aggregation, we performed comparative global transcriptomics analysis using next generation RNA sequencing (RNA-seq). We compared young adult animals fed on th...
ORGANISM(S): Caenorhabditis elegans 
2020-01-14 | E-MTAB-8164 | biostudies-arrayexpress
ProteomicsChronic alcohol exposure during young adulthood attenuates microglial reactivity and downstream immune response pathways in a mouse model of tauopathy later in life
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder marked by the buildup of amyloid-β and tau protein tangles. Alcohol use has been identified as a risk factor for AD; however, the molecular mechanisms underlying this potential causal link remain elusive. An emerging area of resear...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-31 | PXD055552 | Pride
Microglia  alcohol  proteomics  tauopathy  alzheimer’s disease 
TranscriptomicsTranscription profiling by array of human bone marrow hematopoietic stem cells from healthy young and elderly individuals
In the human hematopoietic system, aging is associated with decreased bone marrow cellularity, decreased adaptive immune system function, and increased incidence of anemia and other hematological disorders and malignancies. Recent studies in mice suggest that changes within the hematopoietic stem ce...
ORGANISM(S): Homo sapiens 
2011-11-11 | E-GEOD-32719 | biostudies-arrayexpress
ProteomicsHuman Adipose-Stem-Cell-Derived Small Extracellular Vesicles Modulate Behavior and Glial Cells in Young and Aged Mice Following TBI
Traumatic brain injury (TBI) is a major cause of long-term neurological impairment, with aging amplifying vulnerability and worsening recovery. Older individuals face greater cognitive and motor deficits post-TBI and respond less effectively to treatments, as both aging and TBI independently elevate...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-11 | PXD067584 | Pride
Tbi  aged  small extracellular vesicles (sevs)  human adipose derived stem cells (hasc)  microglia  astrocytes  neuroinflammation 
TranscriptomicsSprouting transcriptome in cortical neurons: young
Selective isolation of total RNA and then whole genome expression analysis of sprouting neurons in peri-infarct cortex of the adult rat after stroke, compared to adjacent neurons that have not sprouted a new connection, in young adult (2 months) and aged (2 years) animals. Two different fluorescent ...
ORGANISM(S): Rattus norvegicus 
2010-11-15 | E-GEOD-24440 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wild type, dcgrA knock out and reconstituted wild type Aspergillus fumigatus to determine the contribution of CgrA to ribosome biogenesis
Study to determine the contribution of CgrA to ribosome biogenesis in Aspergillus fumigatus.
ORGANISM(S): Aspergillus fumigatus 
2008-01-03 | E-MEXP-1324 | biostudies-arrayexpress
UnknownSingle-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes.
Not available
S-EPMC6655561 | biostudies-literature
UnknownChildren and young people's experiences of living with developmental coordination disorder/dyspraxia: A systematic review and meta-ethnography of qualitative research.
Not available
S-EPMC7932121 | biostudies-literature
ProteomicsIdentification of Native Cross-links in Bacillus subtilis Spore Coat Proteins
The resistance properties of the bacterial spores are partially due to spore surface proteins, ~30% of which are said to form an insoluble protein fraction. Previous research has also identified a group of spore coat proteins affected by spore maturation, which exhibit an increased level of inter pr...
ORGANISM(S): Bacillus Subtilis (ncbitaxon:1423) 
2021-01-09 | MSV000086681 | MassIVE
UnknownTwo Alimentary Canal Proteins, Fo-GN and Fo-Cyp1, Act in Western Flower Thrips, Frankliniella occidentalis TSWV Infection.
Not available
S-EPMC9965231 | biostudies-literature
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