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MetabolomicsIntegration of magnetic resonance imaging and protein and metabolite CSF measurements to enable early diagnosis of secondary progressive multiple sclerosis

Molecular networks in neurological diseases are complex. Despite this fact, contemporary biomarkers are in most cases interpreted in isolation, leading to a significant loss of information and power. We present an analytical approach to scrutinize and combine information from biomarkers originati...

2018-08-13 | MTBLS558 | MetaboLights
TranscriptomicsStrand-specific RNA-seq analysis of three streptomycetes
We report the mRNA and small RNA transcriptomes of Streptomyces coelicolor, Streptomyces avermitilis, and Streptomyces venezuelae. We identified dozens of new conserved sRNAs and antisense RNAs, including a prominent group of antisense RNAs termed ‘cutoRNAs’ that result from overlap of the 3′ ends ...
ORGANISM(S): Streptomyces venezuelae 
2013-08-01 | E-GEOD-46008 | biostudies-arrayexpress
UnknownMetabolic dysfunction promoted by mitochondrial DNA mutation burden drives retinal degeneration.
Not available
S-EPMC12324525 | biostudies-literature
Transcriptomicsaffy_rnai_cadpoplars: Transcriptome analysis of RNAi-CAD transgenic poplars
affy_rnai_cadpoplar - affy_rnai_cadpoplars - This experiment aims to characterize global gene expression in young xylem of transgenic RNAi-CAD poplars in comparison to WT poplars. Cinnamyl Alcohol Dehydrogenase (CAD) is the final enzyme involved in the monolignol biosynthesis pathway. Transgenic pop...
ORGANISM(S): Populus tremula x Populus alba 
2011-09-29 | E-GEOD-27063 | biostudies-arrayexpress
TranscriptomicsDKK2 maintains osteotropism, invasiveness and metastatic potential in Ewing Tumors
Ewing tumors (ET) are osteolytic bone cancers mostly affecting children and young adults, and are characterized by early lung and distant bone metastases. Here we identified the dickkopf 2 homolog (DKK2) as a highly over-expressed gene in ET compared to normal tissues, which is critically involved i...
ORGANISM(S): Homo sapiens 
2012-12-21 | E-GEOD-36100 | biostudies-arrayexpress
Transcriptomicsaffy_riz_2011_7-: Transcriptomic analysis of rice leaves challenged with virulent and avirulent Xoo strains
affy_riz_2011_7 - affy_riz_2011_7 - The Bacterial Leaf Blight disease of rice is due to Xanthomonas oryzae pv. oryzae. As for many pathogenic bacteria, it relies on a type 3 secretion system (TTSS) that is devoted to the injection of type 3 effectors (T3Es) into the eukaryotic host cell. These prote...
ORGANISM(S): Oryza sativa 
2012-10-15 | E-GEOD-34192 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of lentivirally-transduced rhesus macaque CD34+ cells long-term following transplant
The occurrence of clonal perturbations and leukemia in patients transplanted with retrovirally-transduced autologous hematopoietic stem and progenitor cells (HSPCs) has stimulated extensive investigation, demonstrating that proviral insertions perturb adjacent proto-oncogene expression. Although enh...
ORGANISM(S): Macaca mulatta 
2013-11-05 | E-GEOD-46032 | biostudies-arrayexpress
UnknownTargeting Androgen Receptor and DNA Repair in Metastatic Castration-Resistant Prostate Cancer: Results From NCI 9012.
Not available
S-EPMC6075827 | biostudies-literature
UnknownClinical, Radiologic, Pathologic, and Molecular Characteristics of Long-Term Survivors of Diffuse Intrinsic Pontine Glioma (DIPG): A Collaborative Report From the International and European Society for Pediatric Oncology DIPG Registries.
Not available
S-EPMC6075859 | biostudies-literature
TranscriptomicsSRSF2 mutations impair hematopoiesis and alter exon recognition
Mutations within genes encoding spliceosomal proteins are the most common class of mutations in patients with myelodysplastic syndromes, yet it is currently not well understood how these mutations impact hematopoiesis or RNA splicing. Here we report that mutations affecting the splicing factor SRSF2...
ORGANISM(S): Homo sapiens 
2015-05-12 | E-GEOD-65349 | biostudies-arrayexpress
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