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MetabolomicsMulti-Omics Unveils Strain-Specific Neuroactive Metabolite Production Linked to Inflammation Modulation by Bacteroides and Their Vesicles

18 Bacteroidetes isoaltes were analyzed for their neuroactive potentail using un-targeted and targeted metabolomics. The bacteria were grown to stationary phase, the supernatant was separated and purified using 0.22 um filter. The metabolome from the supernatant was extracted using standard Metha...

2025-08-12 | MTBLS10526 | MetaboLights
MetabolomicsMulti-level analysis of gut microbiome extracellular vesicles-host interaction reveals a connection to gut-brain axis signaling.

Microbiota-released extracellular vesicles (MEVs) have emerged as a key player in intercellular signaling. However, their involvement in the gut-brain axis has been poorly investigated. In this study, we aimed to investigate the cargo capacity of MEVs for bioactive metabolites and their interacti...

2025-08-12 | MTBLS8494 | MetaboLights
ProteomicsExploring exoproteome of 18 human Bacteroidetes strains from human GIT
The project is exploring nauroactive potential of the Bacteroidetes strains from the human GIT.
ORGANISM(S): Bacteroides cellulosilyticus CAG:158 Bacteroides faecis MAJ27 Parabacteroides johnsonii CL02T12C29 Bacteroides zhangwenhongii Bacteria Bacteroides uniformis CAG:3 Phocaeicola vulgatus 274-1D4 Bacteroidetes bacterium beta1a-PCAi-E3-2 Phocaeicola dorei DSM 17855 Bacteroides ovatus str. 3725 D1 iv Bacteroides finegoldii CAG:203 Bacteroides stercoris CC31F Phocaeicola massiliensis B84634 = Timone 84634 = DSM 17679 = JCM 13223 
2025-05-07 | PXD054243 | Pride
Bacterial exoproteome Lcms 
ProteomicsMulti-Level Analysis of Gut Microbiome Extracellular Vesicles-Host Interaction Reveals a Connection to Gut-Brain Axis Signaling
Microbiota-released extracellular vesicles (MEVs) have emerged as a key player in intercellular signaling. However, their involvement in the gut-brain axis has been poorly investigated. In this study, we aimed to investigate the cargo capacity of MEVs for bioactive metabolites and their interactions...
ORGANISM(S): Bacteroides finegoldii Phocaeicola massiliensis 
2024-11-05 | PXD045162 | Pride
Gut microbiome  extracellular vesicles  neuroactive metabolites  gut-brain axis  bacteroides  γ-aminobutyric acid (gaba) 
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