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MetabolomicsButyrate epigenetically licenses sustained epithelial-T cell crosstalk for intestinal immune tolerance

Butyrate, one of the most abundant microbial-derived metabolites in the gut, is important in regulating intestinal homeostasis. In this study, we used untargeted global metabolomics to landscape the intestinal epithelial cellular metabolites changed by butyrate treatment.

2026-06-26 | MTBLS14301 | MetaboLights
TranscriptomicsTranscription profiling of human colon samples from patients who have colorectal cancer recurrence or are recurrence-free to identify gene expression classifiers of clinical outcome
A common reference experiment design was performed. mRNAs from 149 New Zealand colorectal cancer samples were labeled with Cy5 and a common reference RNA from 12 cell lines were labeled with Cy3. Data were log2 transformed and normalized. Class prediction was performed to identify genes capable of p...
ORGANISM(S): Homo sapiens 
2007-09-18 | E-MEXP-1245 | biostudies-arrayexpress
UnknownEpigenetic therapy using belinostat for patients with unresectable hepatocellular carcinoma: a multicenter phase I/II study with biomarker and pharmacokinetic analysis of tumors from patients in the Mayo Phase II Consortium and the Cancer Therapeutics Research Group.
Not available
S-EPMC3438233 | biostudies-literature
UnknownIs more better? The impact of implementing more interventions for hypertension control in a practice facilitation study for small- and medium-sized practices.
Not available
S-EPMC10514225 | biostudies-literature
TranscriptomicsA sumoylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis
Myc is an oncogenic transcription factor frequently dysregulated in human cancer. To identify pathways supporting the Myc oncogenic program, we employed a genome-wide RNAi screen for Myc-synthetic-lethal (MySL) genes and uncovered a role for the SUMO-activating-enzyme (SAE1/2). Loss of SAE1/2 enzyma...
ORGANISM(S): Homo sapiens 
2011-12-08 | E-GEOD-34055 | biostudies-arrayexpress
UnknownSpatial organization of FcγR and TLR2/1 on phagosome membranes differentially regulates their synergistic and inhibitory receptor crosstalk.
Not available
S-EPMC8238967 | biostudies-literature
UnknownAntagonism between neuropeptides and monoamines in a distributed circuit for pathogen avoidance.
Not available
S-EPMC11063628 | biostudies-literature
UnknownTracking single-particle rotation during macrophage uptake.
Not available
S-EPMC4657870 | biostudies-literature
ProteomicsImpact of the identification strategy on reproducibility of DDA and DIA results
Study of the impact of the identification strategy used for DDA and DIA results
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-11-17 | MSV000081719 | MassIVE
UnknownChild and adolescent mental health and psychosocial support interventions: An evidence and gap map of low- and middle-income countries.
Not available
S-EPMC10445093 | biostudies-literature
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