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Proteomicsco-immunoprecipitation of the Arabidopsis G protein β subunit AGB1
Heterotrimeric guanine nucleotide-binding (G) proteins are composed of Gα, Gβ, and Gγ subunits, and function as molecular switches in signal transduction. In Arabidopsis thaliana there are one canonical Gα (GPA1), three extra-large Gα (XLG1, XLG2 and XLG3), one Gβ (AGB1) and three Gγ (AGG1, AGG2 and...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2018-10-02 | PXD011255 | Pride
Arabidopsis thaliana Agb1 Co-immunoprecipitation Heterotrimeric g protein 
MetabolomicsMechanism of interventional effect and targets of Zhuyu Pill in regulating and suppressing colitis and cholestasis

Zhuyu pill (ZYP) is a traditional Chinese medicine prescription composed of two drugs, Coptis chinensis Franch. and Tetradium ruticarpum (A. Jussieu) T. G. Hartley, and is commonly used in the clinical treatment of diseases of the digestive system. However, the mechanism underly...

2022-11-02 | MTBLS4980 | MetaboLights
TranscriptomicsThe G protein-coupled pH-sensing receptor OGR1 is a regulator of intestinal inflammation
OGR1 is a pH sensing G protein-coupled receptor involved in intestinal homeostasis and inflammation. Up-regulation of genes, mediated by OGR1, in response to extracellular acidification were enriched for inflammation, immune response, actin cytoskeleton and cell adhesion pathways. Microarray profili...
ORGANISM(S): Mus musculus 
2015-04-12 | E-GEOD-60295 | biostudies-arrayexpress
ProteomicsRattus norvegicus lung LC-MS/MS
Male Sprague-Dawley rats were used to establish exhausted-exercise model by motorized rodent treadmill. Yu-Ping-Feng-San at doses of 2.18 g/kg was administrated by gavage before exercise training for 10 consecutive days. Quantitative proteomics was performed for assessing the related mechanism of Yu...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-08-12 | PXD032737 | Pride
Rattus norvegicus Lung tissue Lc-ms/ms 
UnknownPhylogeny and comparative analysis of mitochondrial genomes of <i>Gomphus</i> spp. Pers. (Basidiomycota, Agaricomycetes), with descriptions of <i>G. matijun</i> J.W. Liu & F.Q. Yu and <i>G. bijiensis</i> sp. nov.
Not available
S-EPMC12635650 | biostudies-literature
TranscriptomicsIFN-g Regulates mTORC1, Cellular Metabolism and mRNA Translation to Potentiate Inflammatory Macrophage Activation [RNA-Seq]
IFN-g primes macrophages for enhanced inflammatory activation by TLRs and microbial killing, but little is known about the regulation of cell metabolism or mRNA translation during priming. We found that IFN-g regulates macrophage metabolism and translation in an integrated manner by targeting mTORC1...
ORGANISM(S): Homo sapiens 
2015-06-29 | E-GEOD-66809 | biostudies-arrayexpress
TranscriptomicsIFN-g Regulates mTORC1, Cellular Metabolism and mRNA Translation to Potentiate Inflammatory Macrophage Activation [miRNA-Seq]
IFN-g primes macrophages for enhanced inflammatory activation by TLRs and microbial killing, but little is known about the regulation of cell metabolism or mRNA translation during priming. We found that IFN-g regulates macrophage metabolism and translation in an integrated manner by targeting mTORC1...
ORGANISM(S): Homo sapiens 
2015-06-29 | E-GEOD-66808 | biostudies-arrayexpress
TranscriptomicsComparative transcriptome analysis of Gastrodia elata (Orchidaceae) in response to fungus symbiosis to identify gastrodin biosynthesis-related genes
Gastrodia elata Blume (Orchidaceae) is an important Chinese medicine with several functional components. In the life cycle of G. elata, the orchid develops a symbiotic relationship with two compatible mycorrhizal fungi Mycena spp. and Armillaria mellea during seed germination to form vegetative prop...
ORGANISM(S): Gastrodia elata 
2016-08-23 | E-GEOD-73633 | biostudies-arrayexpress
GenomicsDNA Cytosine Hydroxymethylation Levels Are Distinct Among Peripheral Blood Leukocytes
Peripheral blood leukocytes are the most commonly used surrogates to study epigenome-induced risk and epigenomic response to disease related stress. We considered the hypothesis that the TET enzyme catalyzed hydroxymethylation of 5mC to 5hmC might vary among peripheral blood leukocytes and reflect t...
ORGANISM(S): Homo sapiens 
2016-07-05 | E-GEOD-70519 | biostudies-arrayexpress
GenomicsDHX36-mediated G-quadruplexes unwinding is essential for oocyte and early embryo development in mice
DHX36-mediated G-quadruplexes unwinding is essential for oocyte and early embryo development in mice
PRJNA1108676 | ENA
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