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GenomicsCompensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism: Pol II occupancy profiling by ChIP-Seq in HeLa cell line in the presence or absence of CDK9 inhibition
CDK9 is the kinase subunit of P-TEFb that enables RNA polymerase (Pol) II to transit from promoter-proximal pausing to productive elongation. Although considerable interest exists in CDK9 as a therapeutic target, little progress has been made due to the lack of highly selective inhibitors. Here, we ...
ORGANISM(S): Homo sapiens 
2015-06-17 | E-GEOD-60953 | biostudies-arrayexpress
ProteomicsTime- and dose-resolved proteome of PM2.5 exposure in rat model
this paper used Mass spectrometry, Fast-seq, and catTFRE to study the pattern of 6316 proteins as well as 387 Transcription factors associated with PM2.5 in both short-term and long-term rat injury models.
ORGANISM(S): Rattus Norvegicus 
PXD019404 |
MetabolomicsVGLL4 modulates Paneth cells and sustains intestinal homeostasis.
Paneth cells are defensive cells in the intestinal tract, which secrete niche factors and antimicrobial peptides (AMPs) to maintain the small intestinal stem cell niche and immune homeostasis. Here, we show that Vestigial-like family member 4 (VGLL4) plays a pivotal role in maintaining small intesti...
2026-03-12 | MTBLS10456 | MetaboLights
ProteomicsComprehensive Proteomic Characterization of Scar Formation in Urethral Stricture Disease
Male urethral stricture disease (USD) is characterized by scar formation, whose molecular mechanism is still lack. In this study, we performed comprehensive proteomic landscape of USD with 12 scar tissues and 5 matched normal adjacent tissues (NATs). Comparative analysis disclosed the ECM signaling ...
ORGANISM(S): Homo Sapiens 
PXD053186 |
ProteomicsSerum proteomics identify biomarkers associated with the pathogenesis of idiopathic pulmonary fibrosis
This serum proteomic profile provides rigorous evidence that enables understanding of the heterogeneity of IPF and protein alterations that could help in its diagnosis and treatment decisions.
ORGANISM(S): Homo Sapiens 
PXD052329 |
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