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ProteomicsHOXB13 WT and G84E mass spectrometry
To identify potential cofactors of HOXB13 in suppressing lipogenic programs in prostate cancer cells, we performed tandem affinity purification followed by mass spectrometry analysis of WT and G84E HOXB13 expressed in LNCaP cells. Out of the HOXB13-enriched proteins are previously reported interacto...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD030810 | Pride
Prostate cancer Tandem affinity purification Hoxb13 
UnknownTRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression.
Not available
S-EPMC6258673 | biostudies-literature
UnknownFOXA1 inhibits hypoxia programs through transcriptional repression of HIF1A.
Not available
S-EPMC9464719 | biostudies-literature
UnknownThe common stress responsive transcription factor ATF3 binds genomic sites enriched with p300 and H3K27ac for transcriptional regulation.
Not available
S-EPMC4857411 | biostudies-literature
GenomicsPioneer factor FOXA1 defines GATA2- and AR-mediated transcriptional program in prostate cancer
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-01-11 | E-GEOD-69045 | biostudies-arrayexpress
UnknownAltered chromatin recruitment by FOXA1 mutations promotes androgen independence and prostate cancer progression.
Not available
S-EPMC6796844 | biostudies-literature
GenomicsPioneer factor FOXA1 defines GATA2- and AR-mediated transcriptional program in prostate cancer [ChIP-Seq]
AR is tightly regulated by many transcriptional cofactors, including key pioneer factor such as FOXA1 and GATA2. While FOXA1 was recently shown to be able to redistribute AR across the genome, how GATA2 regulates AR cistrome has not been carefully investigated. Here, we report that, unlike FOXA1, ...
ORGANISM(S): Homo sapiens 
2016-01-11 | E-GEOD-69043 | biostudies-arrayexpress
GenomicsChIP-Seq analysis of ER binding sites in MCF7 breast cancer cells
Estrogen Receptor (ER) is a hormonal transcription factor that plays important roles in breast cancer. It functions primarily through binding to the regulatory regions of target genes containing the consensus ERE motifs. In order to identify ER target genes and re-define the ERE motifs we performed...
ORGANISM(S): Homo sapiens 
2010-02-01 | E-GEOD-19013 | biostudies-arrayexpress
TranscriptomicsSuz12 ChIP-chip using Avi-6k-hu
The polycomb group (PcG) protein, EZH2, possesses oncogenic properties for which the underlying mechanism is unclear. In this set of experiments, we sought to identify a robust set of Suz12-occupied gene promoters in prostate cancer cell lines. Genome-wide location analysis (ChIP-chip) of SUZ12 was ...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-5596 | biostudies-arrayexpress
TranscriptomicsCooperativity and Equilibrium with FOXA1 Define Androgen Receptor Transcriptional Program [array]
Previous studies have shown that FOXA1 defines prostatic AR binding events, the underlying mechanisms of which, however, are incompletely understood. To test whether ectopic AR and FOXA1 can activate AR target genes, we performed adenoviral of LacZ, AR, FOXA1 or AR+FOXA1 proteins in DU145 cells, fo...
ORGANISM(S): Homo sapiens 
2014-06-02 | E-GEOD-54991 | biostudies-arrayexpress
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