Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell, Cell Culture
DISEASE(S): Prostate Adenocarcinoma
SUBMITTER: Xiaodong Lu
LAB HEAD: Jindan Yu
PROVIDER: PXD030810 | Pride | 2023-03-11
REPOSITORIES: Pride
Lu Xiaodong X Fong Ka-Wing KW Gritsina Galina G Wang Fang F Baca Sylvan C SC Brea Lourdes T LT Berchuck Jacob E JE Spisak Sandor S Ross Jenny J Morrissey Colm C Corey Eva E Chandel Navdeep S NS Catalona William J WJ Yang Ximing X Freedman Matthew L ML Zhao Jonathan C JC Yu Jindan J
Nature genetics 20220425 5
HOXB13, a homeodomain transcription factor, critically regulates androgen receptor (AR) activities and androgen-dependent prostate cancer (PCa) growth. However, its functions in AR-independent contexts remain elusive. Here we report HOXB13 interaction with histone deacetylase HDAC3, which is disrupted by the HOXB13 G84E mutation that has been associated with early-onset PCa. Independently of AR, HOXB13 recruits HDAC3 to lipogenic enhancers to catalyze histone deacetylation and suppress lipogenic ...[more]