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TranscriptomicsGene expression profile of HCCs developed in miR-122 knockout mice compared to age-matched wild type mice
Gene expression profiling of HCCs developed in miR-122 knockout mice compared to age-matched wild type mice. The significance of our study is that miR-122 knockout mice spontaneously develop liver tumors and the gene expression profile demonstrated dysregulation of several pathways involved in liver...
ORGANISM(S): Mus musculus 
2012-08-06 | E-GEOD-31731 | biostudies-arrayexpress
TranscriptomicsHsp70 and a Novel Axis of Type 1 Interferon-Dependent Antiviral Immunity in the Measles Virus-Infected Brain
The major inducible 70 kDa heat shock protein (hsp70) is host protective in a mouse model of measles virus (MeV) brain infection. Transgenic constitutive expression of hsp70 in neurons, the primary target of MeV infection, abrogates neurovirulence in neonatal H-2d congenic C57BL/6 mice. A significan...
ORGANISM(S): Mus musculus 
2012-11-14 | E-GEOD-42264 | biostudies-arrayexpress
Transcriptomics17-DMAG treatment in primary CLL B cells
We used microarrays to analyze gene expression following treatment of leukemic B cells with the Hsp90 inhibitor 17-DMAG. Gene expression profiling reveals the role of SOCS3 in cytokine signaling in CLL Primary cells from CLL patients were isolated and treated in vitro with 17-DMAG. Cells were collec...
ORGANISM(S): Homo sapiens 
2016-07-01 | E-GEOD-76546 | biostudies-arrayexpress
TranscriptomicsExpression data from CD19-positive splenic B cells isolated from 1-month old ID4+/-TCL1-tg and ID4+/+TCL1-tg mice
The function of ID4 in CLL development was studied in vivo using TCL1 transgenic mouse model that develop leukemia similar to human CLL. TCL1 mice with ID4 single knockout gene have accelerated CLL progression. Results from the animal study suggest ID4 as a tumor suppressor gene that might regulate ...
ORGANISM(S): Mus musculus 
2010-11-04 | E-GEOD-25100 | biostudies-arrayexpress
UnknownQuantitative DNA methylation analysis identifies a single CpG dinucleotide important for ZAP-70 expression and predictive of prognosis in chronic lymphocytic leukemia.
Not available
S-EPMC3397783 | biostudies-literature
TranscriptomicsExpression Data from Endothelial Cells as a Consequence of Ets2 Signaling in PyMT Tumor Associated Fibroblasts
Tumor associated fibroblasts are known to play an important role in angiogenesis, however the specific signaling pathways playing an important role in this cross talk remain ill defined. Here, we studied how Ets2 transcrpiton factor signaling in tumor associated fibroblasts effected gene expression...
ORGANISM(S): Mus musculus 
2013-12-01 | E-GEOD-44118 | biostudies-arrayexpress
TranscriptomicsAnalysis of liver gene expression profile in male mice fed alcoholic (Lieber-Decarli's) diet and calorie-matched control diet for 6 weeks
Microarray analysis showed dysregulation of genes involved in lipid, xenobiotic and glutathione metabolism as well as those involved in mitochondrial function and cell proliferation in the livers of C57BL6 mice fed alcoholic liquid diet for 6 weeks. We analyzed liver RNA from 4 mice fed alcoholic di...
ORGANISM(S): Mus musculus 
2012-12-19 | E-GEOD-30829 | biostudies-arrayexpress
TranscriptomicsEffect of CSF1R inhibition in tumor macrophages on gene expression in metastatic epithelial cells
Metastasis is the primary cause of mortality in breast cancer patients. Tumor associated macrophages (TAMs) are active collaborators in mediating several steps of the tumor metastatic cascade, but the molecular details governing this collaboration remain ill-defined. Colony Stimulating Factor 1 (CS...
ORGANISM(S): Mus musculus 
2014-03-13 | E-GEOD-55855 | biostudies-arrayexpress
TranscriptomicsExpression Data from Normal or ErbB2 Tumor Fibroblasts With or Without Ets2
The mechanisms involved in epithelium-stroma interactions remain poorly understood, despite the importance of the microenvironment during tumorigenesis. Here, we studied the role of Ets2 transcrpiton factor in tumor associated fibroblasts in the MMTV-ErbB2 mammary tumor model. Inactivation of Ets2...
ORGANISM(S): Mus musculus 
2013-12-01 | E-GEOD-44166 | biostudies-arrayexpress
TranscriptomicsQS wild type and Aldh1a1-/- preadipocytes 2015
The goal of this study was to identify preadipocyte signature genes that are dependent in aldehyde dehydrogenase 1a1 (Aldh1a1) by comparison genomes of the immortalized wild type and Aldh1a1-/- preadipocytes. Gene expression was measured using theAffymetrix GeneChip Mouse Gene ST 2.0 arrays. Murine ...
ORGANISM(S): Mus musculus 
2016-07-03 | E-GEOD-69573 | biostudies-arrayexpress
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