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MetabolomicsMethionine Intervention Induces PD-L1 Expression to Enhance the Immune Checkpoint Therapy Response in MTAP-deleted Osteosarcoma
Osteosarcoma (OS), a malignant bone tumor with limited treatment options, exhibits low sensitivity to immune checkpoint therapy (ICT). Through genomics and transcriptomics analyses, we have identified a subgroup of OS with methylthioadenosine phosphorylase (MTAP) deletion, which contributes to ICT r...
2026-06-09 | MTBLS11985 | MetaboLights
MetabolomicsMetabolite signatures of diverse Camellia sinensis tea populations
Tea plants (Camellia sinensis) present an excellent system to study evolution and diversification of specialized metabolites due to their abundance in classes, numbers and contents. A large number of tea cultivars have been cultivated throughout the world not only because of their adaption to differ...
2020-10-05 | MTBLS1405 | MetaboLights
MetabolomicsGlobal metabolomics of fireflies (Coleoptera: Lampyridae) explore metabolic adaptation to fresh water in insects

Aquatic insects are well-adapted to freshwater environments, but metabolic mechanisms of such adaptations, particularly to primary environmental factors (e.g., hypoxia, water pressure, dark light and abundant microbes), are poorly known. Most firefly species (Coleoptera: Lampyridae) are terrestri...

2022-10-03 | MTBLS4987 | MetaboLights
UnknownMetabolomics Response to Drought Stress in Morus alba L. Variety Yu-711.
Not available
S-EPMC8400578 | biostudies-literature
UnknownA new cave-dwelling spider of the genus Speleoticus (Araneae, Nesticidae) from Sichuan, China
Not available
S-EPMC10463029 | biostudies-literature
TranscriptomicsExpression data from human hematopoietic stem and progenitor compartments from patients with acute myeloid leukemia with normal karyotype and healthy controls
We applied a novel approach of parallel transcriptional analysis of multiple, highly fractionated stem and progenitor populations from patients with acute myeloid leukemia (AML) and a normal karyotype. We isolated phenotypic long-term HSC (LT-HSC), short-term HSC (ST-HSC), and committed granulocyte-...
ORGANISM(S): Homo sapiens 
2012-09-05 | E-GEOD-35008 | biostudies-arrayexpress
UnknownThe analgesic effects of Yu-Xue-Bi tablet (YXB) on mice with inflammatory pain by regulating LXA4-FPR2-TRPA1 pathway.
Not available
S-EPMC11302111 | biostudies-literature
TranscriptomicsTime course profile of umbilical cord blood cells in culture
Despite the importance of inter-cellular communication networks in regulating stem cell fate decisions, very little is known about the topology, dynamics, or functional significance. Using human blood stem cell cultures as an experimental paradigm, we present a novel bioinformatic approach to integ...
ORGANISM(S): Homo sapiens 
2009-07-01 | E-GEOD-16589 | biostudies-arrayexpress
TranscriptomicsGeneration of Induced Pluripotent Stem Cells using Recombinant Proteins
Groundbreaking work demonstrated that ectopic expression of four transcription factors, Oct4, Klf4, Sox2, and c-Myc, could reprogram murine somatic cells to induced pluripotent stem cells (iPSCs) (Takahashi and Yamanaka, 2006), and human iPSCs were subsequently generated using similar genetic manipu...
ORGANISM(S): Mus musculus 
2010-04-09 | E-GEOD-16062 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling by high throughput sequencing of Panax ginseng C.A. Meyer leaf and stem transcriptomes during the leaf-expansion period.
In order to research the ginseng leaf-stem gene expression profiles of and dig out its function genes in the leaf-expansion period, the transcriptomic sequencing technology was set up the first time for five years the transcription of the Panax ginseng leaf-stem in the leaf-expansion period.
ORGANISM(S): Panax ginseng 
2012-07-31 | E-MTAB-937 | biostudies-arrayexpress
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