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TranscriptomicsBarx2 and Pax7 have antagonistic functions in regulation of Wnt signaling and satellite cell differentiation
The canonical Wnt signaling pathway is critical for myogenesis and can induce muscle progenitors to switch from proliferation to differentiation; how Wnt signals integrate with muscle specific regulatory factors in this process is poorly understood. We previously demonstrated that the Barx2 homeobox...
ORGANISM(S): Mus musculus 
2015-10-22 | E-GEOD-53398 | biostudies-arrayexpress
TranscriptomicsA Bcl6-Smrt/Ncor repression program controls atherosclerosis
This SuperSeries is composed of the following subset Series: GSE27001: Inhibition of Bcl6-SMRT/NCoR interactions by an inhibitory peptide affects inflammatory pathways GSE27033: Genome-wide location analysis of SMRT and NCoR in wild-type and Bcl6 knockout macrophages Refer to individual Series
ORGANISM(S): Mus musculus 
2012-03-29 | E-GEOD-27060 | biostudies-arrayexpress
GenomicsBcl6 and NFkB cistromes mediate opposing reulation of the innate immune response
Here, using ChIP-seq, we define the NF-κB cistrome which is comprised of 31,070 cis-acting binding sites responsive to LPS-induced signaling. In addition, we demonstrate that the transcriptional repressor B-cell lymphoma 6 (Bcl-6) regulates nearly a third of the Tlr4-regulated transcriptome and tha...
ORGANISM(S): Mus musculus 
2010-11-24 | E-GEOD-16723 | biostudies-arrayexpress
TranscriptomicsA Master Cistromic Circuit Governing Hepatic Fibrogenesis
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Rattus norvegicus 
2013-04-29 | E-GEOD-41580 | biostudies-arrayexpress
GenomicsGenome-wide location analysis of SMRT and NCoR in wild-type and Bcl6 knockout macrophages
Using ChIP-seq, we reveal the SMRT and NCoR co-repressor cistromes, which each consist of over 30,000 half-shared binding sites. Moreover, we identify Bcl6-bound sub-cistromes for each co-repressor, which are strongly concentrated on NF-κB-driven inflammatory and tissue remodeling genes. These res...
ORGANISM(S): Mus musculus 
2012-03-29 | E-GEOD-27033 | biostudies-arrayexpress
GenomicsSuper-Enhancer-mediated Control of Liver Fibrosis by BET Bromodomain Proteins
Here, we investigate the role of enhancers in myofibroblasts, a cell type that dominates the pathogenesis and progression of tissue fibrosis. We reveal that bromodomain and extra-terminal family members (BETs), an important group of epigenetic readers, are critical for super-enhancer-mediated pro-fi...
ORGANISM(S): Homo sapiens 
2015-12-11 | E-GEOD-58680 | biostudies-arrayexpress
TranscriptomicsOrphan Nuclear Receptors ERRα/γ are competence factors for somatic cell reprogramming
We report the expression profiles of the nuclear receptor family of transcription factors, known regulators of metabolism, during iPSC generation. Unique but overlapping expression patterns were found in iPSCs derived from adipose derived stem cells (ADSCs) and embryonic fibroblasts (human and mouse...
ORGANISM(S): Homo sapiens 
2015-05-27 | E-GEOD-31704 | biostudies-arrayexpress
TranscriptomicsThe role of FGF21 in aging and aging-related diseases
Aging and aging-related diseases represent an increasing burden on modern society. Thus, drugs that retard the aging process are highly desirable. Fibroblast growth factor-21 (FGF21) is a hormone secreted by the liver during fasting that elicits diverse aspects of the adaptive starvation response....
ORGANISM(S): Mus musculus 
2012-10-18 | E-GEOD-39313 | biostudies-arrayexpress
TranscriptomicsIntegral roles for Rev-erb alpha and Rev-erb beta in the circadian clock function
This SuperSeries is composed of the following subset Series: GSE34018: Integral roles for Rev-erb alpha and Rev-erb beta in the circadian clock function [Expression array] GSE34019: Integral roles for Rev-erb alpha and Rev-erb beta in the circadian clock function [ChIP_seq] Refer to individual Serie...
ORGANISM(S): Mus musculus 
2012-03-28 | E-GEOD-34020 | biostudies-arrayexpress
TranscriptomicsIntegral roles for Rev-erb alpha and Rev-erb beta in the circadian clock function [Expression array]
The circadian clock acts at the genomic level to coordinate internal behavioral and physiologic rhythms via the CLOCK-BMAL transcriptional heterodimer. Although the nuclear receptors REV-ERB? and ? have been proposed to contribute to clock function, their precise roles and importance remain unresol...
ORGANISM(S): Mus musculus 
2012-03-28 | E-GEOD-34018 | biostudies-arrayexpress
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