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ProteomicsAn anti-influenza A virus microbial metabolite acts by degrading viral endonuclease PA
The emergence of new highly pathogenic and drug-resistant influenza strains urges the development of novel therapeutics for influenza A virus (IAV). Here, we report the discovery of an anti-IAV microbial metabolite called APL-16-5 that was originally isolated from the plant endophytic fungus Aspergi...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD031993 | Pride
Influenza a virus  proteolysis-targeting chimeras  trim25  phenalenone derivatives  microbial metabolites  antiviral drug 
UnknownAntifungal effects and biocontrol potential of lipopeptide-producing Streptomyces against banana Fusarium wilt fungus Fusarium oxysporum f. sp. cubense.
Not available
S-EPMC10172682 | biostudies-literature
UnknownGut microbial community plasticity as a climate shield mediating sea cucumber resilience to ocean acidification and warming.
Not available
S-EPMC12596727 | biostudies-literature
UnknownCan virtual reality technology be used for empathy education in medical students: a randomized case-control study.
Not available
S-EPMC11536554 | biostudies-literature
ProteomicsIdentification of poly(ADP-ribosyl)ation targets reveals a role of DAWDLE in Arabidopsis immunity
Our stardy uncovers many previously unknown PARylation targets and points to the distinct functions of small RNA biogenesis respectively
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2018-10-27 | PXD004267 | Pride
Arabdopsis immunity Poly(adp-ribosyl)ation Dawdle 
UnknownPARylation of the forkhead-associated domain protein DAWDLE regulates plant immunity.
Not available
S-EPMC5283580 | biostudies-literature
UnknownTafamidis improves myocardial longitudinal strain in A97S transthyretin cardiac amyloidosis.
Not available
S-EPMC10785723 | biostudies-literature
TranscriptomicsGene expression of SUM159-mir100 ALDH+ and ALDH- cells from CTRL or mir100-overexpressing group
Emerging evidence suggest that miRNAs play an essential role in self-renewal and differentiation of normal and malignant stem cells by regulating the expression of key stem cell regulatory genes. Here we demonstrate that mir-100 expression is related to cellular differentiation state with lowest exp...
ORGANISM(S): Homo sapiens 
2014-12-04 | E-GEOD-59361 | biostudies-arrayexpress
TranscriptomicsClaudin 1 mediates TNF alpha-induced gene expression and cell migration in human lung carcinoma cells
Epithelial-mesenchymal transition (EMT) is an important mechanism in carcinogenesis. To determine the mechanisms that are involved in the regulation of EMT is crucial to develop new biomarkers and therapeutic targets towards cancers. In this study, when TGFß1 and TNFa were used to induce EMT in hum...
ORGANISM(S): Homo sapiens 
2012-06-12 | E-GEOD-32254 | biostudies-arrayexpress
UnknownSafety and efficacy of lithium in combination with riluzole for treatment of amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial.
Not available
S-EPMC3071495 | biostudies-literature
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