After positive selection in the thymus, the newly generated single positive (SP) thymocytes are phenotypically and functionally immature and undergo apoptosis upon antigen stimulation. In the thymic medullary microenvironment, SP cells progressively acquire immunocompetence. Negative selection to r...
This project contains the raw MS data that identified PDZD8 as a substrate of AMPK on the MAM of ER-mitochondria contact. They also revealed that site T527 is an AMPK-phosphorylation site.