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MetabolomicsX chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction

Statin drugs lower blood cholesterol levels for cardiovascular disease prevention. Women are more likely than men to experience adverse statin effects, particularly new-onset diabetes (NOD) and muscle weakness. Here we find that impaired glucose homeostasis and muscle weakness in statin-treated f...

2024-05-23 | MTBLS9677 | MetaboLights
TranscriptomicsSex-dependent and -independent X-chromosome histone modifications in Drosophila melanogaster
Drosophila X chromosomes are subject to dosage compensation in males and are known to have a specialized chromatin structure in the male soma. We are interested in how specific chromatin structure change contributes to X chromosome hyperactivity and dosage compensation. We have conducted a global a...
ORGANISM(S): Drosophila melanogaster 
2010-01-11 | E-GEOD-15593 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of brains, hindlimbs and tails of Xenopus laevis tadpoles after treatment with thyroid hormone
Premetamorphic Xenopus laevis tadpole tail respond to thyroid hormone by resorption. The goal of this experiment is to identify the genes involved in the TH-induced resorption tadpole tail and compare it to TH-induced proliferation and differentiation program in tadpole limb and brain. Xenopus tadpo...
ORGANISM(S): Xenopus laevis 
2006-11-08 | E-MNIA-94 | biostudies-arrayexpress
GenomicsFragaria x ananassa
Fragaria x ananassa Raw sequence reads
PRJNA1505151 | ENA
ProteomicsCandidate proteins involved in the calyx abscission process of ‘Kuerlexiangli’ (Pyrus sinkiangensis Yu) identified by iTRAQ analysis
‘Kuerlexiangli’ (Pyrus sinkiangensis Yu) is an important market pear in China. The shape and quality of the fruit is negatively affected by the presence of a persistent calyx. Here, to explore the molecular mechanism of calyx abscission, we designed an experiment to compare protein expression at two...
ORGANISM(S): Pyrus x bretschneideri 
2020-06-17 | PXD012499 | Pride
Itraq Pear Calyx abscission Differentially abundant proteins 
UnknownX-ray phase-contrast tomography of cells manipulated with an optical stretcher.
Not available
S-EPMC11226146 | biostudies-literature
TranscriptomicsSperm but not oocyte DNA methylome is inherited by zebrafish early embyros
5-methylcytosine is a major epigenetic modification sometimes called "the fifth nucleotide". However, our knowledge of how offspring inherit the DNA methylome from parents is limited. We generated nine single-base resolution DNA methylomes including zebrafish gametes and early embryos. The...
ORGANISM(S): Danio rerio 
2013-05-20 | E-GEOD-44075 | biostudies-arrayexpress
TranscriptomicsExpression in Aneuploid Drosophila S2 Cells
Chromosomal and segmental aneuploidies are usually lethal or common features of cancer cells and variety of disease, but little is known about how copy number relates to gene expression. Drosophila males have a single X chromosome and two sets of autosomes, but X chromosome and autosome transcripts ...
ORGANISM(S): Drosophila melanogaster 
2010-01-11 | E-GEOD-16344 | biostudies-arrayexpress
UnknownX-chromosome genetic association test accounting for X-inactivation, skewed X-inactivation, and escape from X-inactivation.
Not available
S-EPMC4127090 | biostudies-literature
ProteomicsTargeting microRNA-dependent control of X chromosome inactivation improves the Rett Syndrome phenotype
The X chromosome inactivation (XCI) is induced by Xist long non-coding RNA and protein-coding genes. However, the small non-coding RNA function in XCI remains unidentified. Our genome-wide, loss-of-function CRISPR/Cas9 screen in female fibroblasts examines the role of microRNA (miRNAs) in XCI. A str...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-09 | PXD064749 | Pride
Lcms Mus mus Chirp-ms 
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