Sort   by:  
 Page size 
TranscriptomicsHigh resolution methylome analysis reveals widespread functional hypomethylation during adult human erythropoiesis
Differentiation of hematopoietic stem cells to red cells requires coordinated expression of numerous erythroid genes. To understand the regulatory mechanisms governing lineage commitment we conducted a high resolution methylomic and transcriptomic analysis of six major stages of human erythroid diff...
ORGANISM(S): Homo sapiens 
2013-02-05 | E-GEOD-44054 | biostudies-arrayexpress
GenomicsGenome wide hydroxymethylation tested using the HELP-GT assay shows redistribution in cancer
Background: 5-hydroxymethylcytosine (5-hmC) is a recently discovered epigenetic modification that is altered in cancers. Genome wide assays for 5-hmC determination are needed as many of the techniques commonly used to assay 5-methylcytosine (5-mC), including conventional methyl-sensitive restriction...
ORGANISM(S): Homo sapiens 
2013-07-30 | E-GEOD-42723 | biostudies-arrayexpress
TranscriptomicsLong Noncoding RNA HNF1A-AS1 Regulates Proliferation and Migration in Esophageal Adenocarcinoma Cells
Objectives: Long non-coding RNAs (lncRNAs) have been shown to play important roles in the development and progression of cancer. However, functional lncRNAs and their downstream mechanisms are largely unknown in the molecular pathogenesis of esophageal adenocarcinoma (EAC) and its progression. Desig...
ORGANISM(S): Homo sapiens 
2013-10-21 | E-GEOD-48240 | biostudies-arrayexpress
TranscriptomicsAnalysis of DNA methylation changes in normal human hematopoietic stem and progenitor cells
DNA methylation analysis on purified human long-term and short-term hematopoietic stem cells (LT-HSC, ST-HSC), common myeloid and megakaryocyte-erythrocyte progenitor cells (CMP, MEP) using HELP arrays. FACS-purified hematopoietic stem and progenitor cell (HSPC) subsets were analyzed for changes in ...
ORGANISM(S): Homo sapiens 
2014-02-07 | E-GEOD-52151 | biostudies-arrayexpress
TranscriptomicsAnalysis of RNA expression changes in normal human hematopoietic stem and progenitor cells
RNA expression analysis on purified human long-term and short-term hematopoietic stem cells (LT-HSC, ST-HSC), common myeloid and megakaryocyte-erythrocyte progenitor cells (CMP, MEP) using microarrays. FACS-purified hematopoietic stem and progenitor cell (HSPC) subsets were analyzed for changes in R...
ORGANISM(S): Homo sapiens 
2014-02-07 | E-GEOD-52150 | biostudies-arrayexpress
GenomicsHydroxymethylation at gene regulatory regions directs stem cell commitment during erythropoiesis
CD34 positive hematopoietic stem cells were differentiated into erythroid lineage. Next generation sequencing (NGS) of 5hmC affinity pulldown and RNAseq were performed in four time point of different stages of erythroid differentiation. 4 RNA-Seq Samples (d0, d3, d7 and d10); 4 affinity-pulldown (d...
ORGANISM(S): Homo sapiens 
2014-03-28 | E-GEOD-40243 | biostudies-arrayexpress
ProteomicsMass spectrometry data of PBMCs after PBS/SEMA3G treatment
The semaphorins encompass a substantial family of secreted and transmembrane glycoproteins, originally recognized as pivotal factors in guiding axonal growth during the development of neural circuitry. Recent studies have uncovered diverse functions of semaphorins in a wide array of immune responses...
ORGANISM(S): Homo Sapiens 
PXD057174 |
Sort   by:  
 Page size