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ProteomicsAge-Associated Proteomic Hallmarks and Potential Clinically Actionable Targets of Colorectal Cancer
Colorectal cancer (CRC) is the third most frequent cancer usually occurring in elderly persons. However, the molecular characteristics of old-onset CRC remain largely unknown. Here we performed proteomic profiling from 52 CRC tumors and their paired non-cancerous adjacent tissues and delineated the ...
ORGANISM(S): Homo Sapiens 
2021-04-16 | PXD022714 |
ProteomicsPhenotypic heterogeneity analysis of APC-mutant colon cancer by proteomics and phosphoproteomics identifies RAI14 as a key prognostic determinant
Adenomatous polyposis coli (APC) is an important tumor suppressor and most directly related to the regulation of WNT/β-catenin signaling pathway. APC mutation has been identified as an early event in more than 80% of sporadic colorectal cancers (CRCs). However, obvious prognostic differences are obs...
ORGANISM(S): Homo Sapiens 
2022-11-10 | PXD038081 |
ProteomicsDeciphering the clinical significance and kinase functions of GSK3α in colon cancer by proteomics and phosphoproteomics
In this study, paired tumors and distant normal tissues (DNTs) collected from 78 treatment-naïve colon cancer patients were subjected to tandem mass tag (TMT)-based proteomics. We found that the expression of GSK3α, but not GSK3β, was significantly correlated with the overall survival (OS) of colon ...
ORGANISM(S): Homo Sapiens 
2023-03-03 | PXD038830 |
ProteomicsIntegrative omics reveals magnesium deficiency as a driver factor of colorectal cancer
Magnesium (Mg) deficiency is associated with increased risk and malignancy of colorectal cancer (CRC), but the underlying mechanisms remain elusive. In our study, we used genomic, proteomic, and phosphoproteomic data to reveal the effects of low Mg content on genomic instability and tumor metastasis...
ORGANISM(S): Homo Sapiens 
PXD042746 |
ProteomicsLow-input redoxomics facilitates global identification of metabolic regulators of oxidative stress in the gut
we developed a low-input and user-friendly pipeline for the simultaneous profiling of five distinct Cys states with regional resolution in the gut of monkeys, including free SH, total Cys oxidation (Sto), sulfenic acid (SOH), S-nitrosylation (SNO), and S-glutathionylation (SSG), shedding light on re...
ORGANISM(S): Macaca Fascicularis Fascicularis Homo Sapiens Mus Musculus 
2024-12-16 | PXD053818 |
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