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TranscriptomicsA dysregulated Acetyl/SUMO switch of FXR promotes hepatic inflammation in obesity
Acetylation of transcriptional regulators is normally dynamically regulated by nutrient status but is often persistently elevated in nutrient-excessive obesity conditions. We investigated the functional consequences of such aberrantly elevated acetylation of the nuclear receptor FXR as a model. Prot...
ORGANISM(S): Mus musculus 
2014-10-17 | E-GEOD-62414 | biostudies-arrayexpress
ProteomicsInvestigating the off-target effects of Pro-BA using label-free and TMTpro quantitative proteomics
Nevertheless, in-depth characterization of the proteome could reveal unknown off-targets of Pro-BA. To address this issue, we repeated the same experiment but extended MS analysis time to 2 hours in this revision, which will be elaborated in the next point. Nonetheless, the computed p-value of ALK p...
ORGANISM(S): Homo Sapiens 
2025-03-25 | PXD062245 |
ProteomicsGlobal Profiling of RNA-Binding Protein Target Sites by LACE-seq
Proteomic analysis of Ago2-/- oocytes revealed that Ago2 interacted with endogenous small interfering RNAs (endo-siRNAs) to repress mRNA translation globally.
ORGANISM(S): Mus Musculus 
PXD025846 |
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