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UnknownDNA methylation and transcriptome analysis reveal epigenomic differences among three macaque species.
Not available
S-EPMC10853583 | biostudies-literature
TranscriptomicsHigh Resolution Mapping of RNA Polymerases Identifies Mechanisms of Sensitivity and Resistance to BET Inhibitors in t(8;21) AML
Bromodomain and extra-terminal domain (BET) family inhibitors offer a new approach to treating hematological malignancies. We used precision nuclear run-on transcription sequencing (PRO-seq) to create high-resolution maps of active RNA polymerases across the genome in t(8;21) acute myeloid leukemia ...
ORGANISM(S): Homo sapiens 
2016-07-15 | E-GEOD-83660 | biostudies-arrayexpress
TranscriptomicsGenome-wide measurement of RNA folding energies
RNA structural transitions are important in the function and regulation of RNAs. Here, we reveal a layer of transcriptome organization in the form of RNA folding energies. By probing yeast RNA structures at different temperatures, we obtained relative melting temperatures (Tm) for RNA structures in ...
ORGANISM(S): Saccharomyces cerevisiae 
2012-09-09 | E-GEOD-39680 | biostudies-arrayexpress
TranscriptomicsExpression data from skeletal muscles of flies with muscle-specific overexpression of Foxo or Mnt
Skeletal muscle senescence influences whole organism aging, yet little is known on the relay of pro-longevity signals from muscles to other tissues. We performed an RNAi screen in Drosophila for muscle-released cytokines ('myokines') regulating lifespan and identified Myoglianin, the homolog of huma...
ORGANISM(S): Drosophila melanogaster 
2014-07-02 | E-GEOD-39877 | biostudies-arrayexpress
TranscriptomicsIdentification and characterization of cold responsive microRNAs in tea plant (Camellia sinensis) based on high-throughput sequencing and their targets using degradome analysis [microarray]
Solexa sequencing technology was used to perform high throughput sequencing of the small RNA library from the cold treatment of tea leaves. Subsequently, aligning these sequencing date with plant known miRNAs, we characterized 112 C. sinensis conserved miRNAs. In addition, 215 potential candidate mi...
ORGANISM(S): Camellia sinensis 
2015-05-14 | E-GEOD-53632 | biostudies-arrayexpress
ProteomicsTranscriptomic and phosphoproteomic profiling and metabolite analyses reveal the mechanism of NaHCO3-induced organic acid secretion in grapevine roots
Organic acid secretion is a widespread physiological response of plants to alkalinity. However, the features of alkali-induced secretion of organic acid and the underlying mechanism are poorly understood. Herein, it was indicated that oxalate was the main organic acid synthesized and secreted in vin...
ORGANISM(S): Vitis vinifera (Grape) 
2019-11-11 | PXD013746 | Pride
Transcriptome Organic acid secretion Phosphoproteome Grapevine Alkali stress 
ProteomicsChlamydomonas cpl3 mutant proteomics
This project aims to identify proteins with increased or decreased abundance in the photosynthetically-deficient cpl3 mutant compared to the wild type.
ORGANISM(S): Chlamydomonas reinhardtii 
2019-02-25 | PXD012560 | Pride
Algae Lc-ms Photosynthesis Tmt labeling Chlamydomonas 
UnknownCorrelations between peripheral blood biomarkers and clinical outcomes in advanced non-small cell lung cancer patients who received immunotherapy-based treatments.
Not available
S-EPMC8743518 | biostudies-literature
MetabolomicsDNA-PKcs drives CKD progression by activating TAF7/RAPTOR/mTORC1 signaling-mediated metabolic reprogramming

Kidney injury initiates epithelial dedifferentiation and myofibroblast activation during the progression of chronic kidney disease (CKD). Herein, we found that the expression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) was significantly increased in the kidney tissues of both CKD...

2023-01-25 | MTBLS5971 | MetaboLights
ProteomicsCD81 facilitates tumor cell clustering and metastasis in triple negative breast cancer
Tumor-initiating cells with reprogramming plasticity and/or de-differentiation attributes have been thought to initiate primary tumor development as well as to regenerate secondary tumors in metastatic organs; however, the molecular mechanisms are not fully understood. We previously found that breas...
ORGANISM(S): Homo Sapiens (human) 
2022-10-18 | PXD029529 | JPOST Repository
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