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TranscriptomicsIL-10 from intestinal macrophages prevents excessive innate immune responses to bacteria by limiting IL-23 synthesis
Innate immune responses must be regulated in the intestine to prevent excessive inflammation. Here, using gene reporter mice, we show that a subset of mouse colonic macrophages constitutively produced the anti-inflammatory cytokine IL-10. In mice infected with Citrobacter rodentium, which is consid...
ORGANISM(S): Mus musculus 
2015-05-12 | E-GEOD-58677 | biostudies-arrayexpress
TranscriptomicsThe alarmin IL-33 amplifies an immune response in the degenerating retina
ST2 heterodimerizes with IL-1RAcp to form the receptor for IL-33, which is primarily associated with allergic inflammation by inducing Th2 responses. Recently, however, IL-33 was found to be expressed in the central nervous system and in retinal Muller cells which imply functions, as yet undescribed...
ORGANISM(S): Mus musculus 
2015-12-17 | E-GEOD-74695 | biostudies-arrayexpress
ProteomicsClove (Syzygium aromaticum) and its bioactive constituent eugenol alleviate psoriatic inflammation by modulating the IL-36/IL-17A axis: A proteomic and mechanistic study
An imiquimod (IMQ)-induced psoriasis-like mouse model was employed to assess the therapeutic effects of orally administered clove extract and eugenol. iTRAQ-based LC–MS/MS proteomics were performed to identify molecular alterations, followed by bioinformatics analyses.
ORGANISM(S): Mus musculus (Mouse) 
2026-05-19 | PXD077433 | Pride
Syzygium aromaticum  eugenol  psoriasis  interleukin-17a  interleukin-36  proteomics 
TranscriptomicsGeneration of clinical grade CD19-specific CAR-modified CD8+ memory stem cells for the treatment of B-cell malignancies
Long-lived, self-renewing, multipotent T memory stem cells (TSCM) can trigger profound and sustained tumor regression but their rareness poses a major hurdle to their clinical application. Presently, clinically compliant procedures to generate relevant numbers of this T cell population are undefined...
ORGANISM(S): Homo sapiens 
2016-06-29 | E-GEOD-68003 | biostudies-arrayexpress
TranscriptomicsSIRT1 negatively regulates the differentiation of IL-9-producing CD4+T cells
Distinct metabolic programs support the differentiation of CD4+T cells into their separate lineages. In this study, we investigated metabolic mechanisms underlying the differentiation of IL-9 producing-CD4+T cells (TH9) in allergic airway inflammation and cancerous tumors. We found here that SIRT1 n...
ORGANISM(S): Mus musculus 
2016-06-14 | E-GEOD-79607 | biostudies-arrayexpress
UnknownA Probiotic Lactobacillus gasseri Alleviates Escherichia coli-Induced Cognitive Impairment and Depression in Mice by Regulating IL-1β Expression and Gut Microbiota.
Not available
S-EPMC7697804 | biostudies-literature
TranscriptomicsDifferential Expressions of miRNAs in resting and activated human in vitro-differentiated NK cells
To investigate miRNA expressions of miRNA upon activation. In vitro-differentiated human NK cells were freshly incubated in the presence of IL15 after 24h deprivation of IL-15. The cells were harvested at the times (0h, resting-Sample 1 and 2; 6h, activated-Sample 3 and 4) and analyzed by microarray...
ORGANISM(S): Homo sapiens 
2011-11-21 | E-GEOD-32411 | biostudies-arrayexpress
UnknownTRAF6 mediates IL-1β/LPS-induced suppression of TGF-β signaling through its interaction with the type III TGF-β receptor.
Not available
S-EPMC3299683 | biostudies-literature
UnknownIL-4 drives exhaustion of CD8+ CART cells.
Not available
S-EPMC11393358 | biostudies-literature
MetabolomicsMetabolomic analysis of riboswitch containing E. coli recombinant expression system
In this study we have employed metabolomics approaches to understand the metabolic effects of producing enhanced green fluorescent protein (eGFP) as a recombinant protein in Escherichia coli cells. This metabolic burden analysis was performed against a number of recombinant expression systems and co...
2017-11-16 | MTBLS393 | MetaboLights
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