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TranscriptomicsCross-talk between 4-1BB and TLR1-TLR2 signaling in CD8+ T cells regulates TLR2’s costimulatory effects
The activation of TLR-MyD88 (Toll like receptor- Myeloid differentiation factor 88) signaling within T cells functions as a potent costimulatory signal that boosts antitumor and antiviral responses. However, the molecular mechanisms underlying the costimulatory processes are poorly understood. We co...
ORGANISM(S): Mus musculus 
2016-06-14 | E-GEOD-79475 | biostudies-arrayexpress
TranscriptomicsGenomic analysis of xCT-mediated regulatory network: identification of novel targets against AIDS-associated lymphoma
Kaposi’s sarcoma-associated herpesvirus (KSHV) is the etiological agent of primary effusion lymphoma (PEL), a rapidly progressing malignancy mostly arising in HIV-infected patients. Even under conventional chemotherapy, PEL continues to portend nearly 100% mortality within several months, which ur...
ORGANISM(S): Homo sapiens 
2015-11-23 | E-GEOD-65418 | biostudies-arrayexpress
Transcriptomicsc-MET inhibitor inducing KSHV+ primary effusion lymphoma apoptosis
KSHV is a principal causative agent of primary effusion lymphoma (PEL). Despite this knowledge about the close relationship between HGF/c-MET network and solid tumors development, the role of HGF/c-MET in KSHV-related malignancies remains mostly unclear. We report that HGF/c-MET pathway is highly ac...
ORGANISM(S): Homo sapiens 
2016-01-05 | E-GEOD-70594 | biostudies-arrayexpress
TranscriptomicsGene expression signature predicts induction treatment response and clinical outcome in adult Colombian patients with B-acute lymphoblastic leukemia
Background. B-Acute lymphoblastic leukemia (B-ALL) represents a hematologic malignancy with poor clinical outcome and low survival rates in adult patients. Only 61% of Colombian adult patients with ALL achieve complete remission and a median overall survival of less than 11.3 months and event-free s...
ORGANISM(S): Homo sapiens 
2016-04-06 | E-GEOD-76349 | biostudies-arrayexpress
UnknownNovel immunomodulatory properties of adenosine analogs promote their antiviral activity against SARS-CoV-2
The COVID-19 pandemic reminded us of the urgent need for new antivirals to control emerging infectious diseases and potential future pandemics. Immunotherapy has revolutionized oncology and could complement the use of antivirals, but its application to infectious diseases remains largely unexplored....
S-SCDT-10_1038-S44319-024-00189-4 | biostudies-other
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