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TranscriptomicsImpact of miRNAs modulation on regulatory networks and pathways involved in colon cancer and metastasis development
Originally linked with development and differentiation, the role of microRNAs (miRNAs) in many important biological processes has emerged and dysregulation of miRNA expression has been connected with cancer pathogenesis. The association between abnormal expression levels of miRNAs and colon cancer...
ORGANISM(S): Homo sapiens 
2014-01-16 | E-GEOD-35834 | biostudies-arrayexpress
TranscriptomicsExpression data from bone marrow derived- and tumor induced- CD11b+ MDSC
Tumor growth is associated with a profound alteration of myelopoiesis, leading to recruitment of immunosuppressive cells known as myeloid-derived suppressor cells (MDSCs). Analyzing the cytokines affecting myelo-monocytic differentiation produced by various experimental tumors, we found that GM-CSF...
ORGANISM(S): Mus musculus 
2010-06-16 | E-GEOD-21927 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse CD11b cells purified from mouse spleen from umor-free and tumor-bearing mice
Active suppression of tumor-specific T lymphocytes can limit the immune-surveillance and immunotherapy efficacy. While tumor-recruited CD11b+ myeloid cells are known mediators of tumor-associated immune dysfunction, the true nature of these suppressive cells and the fine biochemical pathways governi...
ORGANISM(S): Mus musculus 
2009-04-29 | E-GEOD-5455 | biostudies-arrayexpress
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