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UnknownReversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly.
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S-EPMC7611853 | biostudies-literature
ProteomicsReversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly
Cells respond to stress by blocking translation, rewiring metabolism, and forming transient mRNP assemblies called stress granules (SGs). After stress release, re-establishing homeostasis requires energy-consuming processes. However, the molecular mechanisms whereby cells restore energy production t...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-08-17 | PXD026060 | Pride
Srm Cdc19 Aggregation 
ProteomicsAn Outer Membrane Protein-Targeting Antibiotic Against Resistant Gram-Negative Bacterial Pathogens
There is an urgent need for novel antibiotics against carbapenem and 3rd generation cephalosporin-resistant Gram-negative pathogens, for which the last-resort antibiotics have lost most of their efficacy. We describe here a novel class of synthetic antibiotics that was inspired from natural product-...
ORGANISM(S): Escherichia Coli (ncbitaxon:562) 
2020-02-04 | MSV000084899 | MassIVE
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