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Transcription termination pathways mitigate the detrimental consequences of unscheduled promiscuous initiation occurring at hundreds of thousands of genomic cis-regulatory elements. The Restrictor complex, composed of the Pol II-interacting protein WDR82 and the RNA-binding protein ZC3H4, suppresses...
ORGANISM(S): Homo sapiens (Human) 
2024-05-23 | PXD043638 | Pride
ZC3H4 restricts non-coding transcription in human cells
RNA sequencing of human keratinocytes infected with HPV16 in ZC3H4 knockdown
The human genome encodes many thousands of non-coding RNAs. A majority of these are curtailed by early transcriptional termination followed by rapid degradation. The mechanisms and factors responsible for restricting non-coding transcription in this fashion are poorly characterised, but these RNAs v...
ORGANISM(S): Homo sapiens 
2021-08-06 | GSE163015 | GEO
ARS2 instructs early transcription termination-coupled RNA decay by recruiting ZC3H4 to nascent transcripts
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