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TranscriptomicsRole of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation (4C-seq)
Cancer cells frequently depend on chromatin regulatory activities to maintain a malignant phenotype. Here, we show that leukemia cells require the mammalian SWI/SNF chromatin remodeling complex for their survival and aberrant self-renewal potential. While Brg1, an ATPase subunit of SWI/SNF, is known...
ORGANISM(S): Mus musculus 
2013-12-02 | E-GEOD-52595 | biostudies-arrayexpress
TranscriptomicsQuantitative analysis of chromatin interactions upon copy number variation at mouse 4E2
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2016-07-03 | E-GEOD-64360 | biostudies-arrayexpress
TranscriptomicsQuantitative analysis of chromatin interactions upon copy number variation at mouse 4E2 [4C-seq]
The three-dimensional organization of chromatin has a critical impact on the regulation of gene expression. However, little is known about the effect of DNA copy number variants (CNVs) on chromatin organization. We performed an allele-specific chromatin conformation and gene expression analysis of w...
ORGANISM(S): Mus musculus 
2016-07-03 | E-GEOD-64358 | biostudies-arrayexpress
TranscriptomicsTransient Pairing of Homologous Oct4 Alleles Accompanies the Onset of Embryonic Stem Cell Differentiation
The relationship between chromatin organization and transcriptional regulation is an area of intense investigation. We have characterized the spatial relationships between alleles of the Oct4, Sox2, and Nanog genes in single cells during the earliest stages of mouse embryonic stem cell (ESC) differe...
ORGANISM(S): Mus musculus 
2015-02-03 | E-GEOD-65510 | biostudies-arrayexpress
TranscriptomicsQuantitative analysis of chromatin interactions upon copy number variation at mouse 4E2 [RNA-seq]
The three-dimensional organization of chromatin has a critical impact on the regulation of gene expression. However, little is known about the effect of DNA copy number variants (CNVs) on chromatin organization. We performed an allele-specific chromatin conformation and gene expression analysis of w...
ORGANISM(S): Mus musculus 
2016-07-03 | E-GEOD-64359 | biostudies-arrayexpress
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