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ProteomicsZFP462 safeguards neural lineage specification by targeting G9A/GLP-mediated heterochromatin to silence enhancers
ZNF462 haploinsufficiency is linked to Weiss-Kruszka Syndrome, a genetic disorder characterized by neurodevelopmental defects including Autism. Though conserved in vertebrates and essential for embryonic development the molecular functions of ZNF462 remain unclear. We identified its murine homolog Z...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD037238 | Pride
Stem cells Lineage specification and heterochromatin Transcription factors Zfp462 
UnknownZFP462 safeguards neural lineage specification by targeting G9A/GLP-mediated heterochromatin to silence enhancers.
Not available
S-EPMC10038669 | biostudies-literature
GenomicsZfp462 regulates the pluripotency of embryonic stem cells by cooperating with the core transcriptional network
Zfp462 regulates the pluripotency of embryonic stem cells by cooperating with the core transcriptional network
PRJNA1007652 | ENA
GenomicsZFP462 safeguards neural lineage specification by targeting G9A/GLP mediated heterochromatin to silence enhancers
ZFP462 safeguards neural lineage specification by targeting G9A/GLP mediated heterochromatin to silence enhancers
PRJNA732185 | ENA
GenomicsZFP462 safeguards neural lineage specification by targeting G9A/GLP mediated heterochromatin to silence enhancers [QuantSeq]
ZFP462 safeguards neural lineage specification by targeting G9A/GLP mediated heterochromatin to silence enhancers [QuantSeq]
PRJNA735763 | ENA
GenomicsZFP462 safeguards neural lineage specification by targeting G9A/GLP mediated heterochromatin to silence enhancers [RNA-seq]
ZFP462 safeguards neural lineage specification by targeting G9A/GLP mediated heterochromatin to silence enhancers [RNA-seq]
PRJNA735881 | ENA
GenomicsZFP462 safeguards neural lineage specification by targeting G9A/GLP mediated heterochromatin to silence enhancers [ATAC-seq]
ZFP462 safeguards neural lineage specification by targeting G9A/GLP mediated heterochromatin to silence enhancers [ATAC-seq]
PRJNA735882 | ENA
GenomicsZFP462 safeguards neural lineage specification by targeting G9A/GLP mediated heterochromatin to silence enhancers [ChIP-seq]
ZFP462 safeguards neural lineage specification by targeting G9A/GLP mediated heterochromatin to silence enhancers [ChIP-seq]
PRJNA736986 | ENA
TranscriptomicsZFP462 safeguards neural lineage specification by targeting G9A/GLP mediated heterochromatin to silence enhancers
ZNF462 haploinsufficiency is linked to Weiss–Kruszka syndrome, a genetic disorder characterized by neurodevelopmental defects, including autism. Though conserved in vertebrates and essential for embryonic development, the molecular functions of ZNF462 remain unclear. We identified its murine homolog...
ORGANISM(S): Mus musculus 
2023-01-04 | GSE175369 | GEO
TranscriptomicsZfp462 regulates the pluripotency of embryonic stem cells by cooperating with the core transcriptional network
Zfp462 is a vertebrate-specific C2H2-type transcription factor that has been found to play a crucial role in chromatin assembly and heterochromatin-mediated transcriptional silencing. However, its exact function in regulating the pluripotency of embryonic stem cells (ESCs) remains poorly understood....
ORGANISM(S): Mus musculus 
2024-03-01 | GSE241288 | GEO
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