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UnknownZFTA-RELA Dictates Oncogenic Transcriptional Programs to Drive Aggressive Supratentorial Ependymoma.
Not available
S-EPMC8418998 | biostudies-literature
GenomicsZFTA-RELA Dictates Oncogenic Transcriptional Programs to Drive Aggressive Supratentorial Ependymoma
ZFTA-RELA Dictates Oncogenic Transcriptional Programs to Drive Aggressive Supratentorial Ependymoma
PRJNA679065 | ENA
ProteomicsHistone serotonylation regulates ependymoma tumorigenesis through neurodevelopmental pathways
Bidirectional communication between tumors and neurons has emerged as a key facet of the tumor microenvironment that drives malignancy. Another hallmark feature of cancer is epigenomic dysregulation, where alterations in gene expression influences cell states and interactions with the tumor microenv...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-09 | PXD048170 | Pride
Epigenetic regulation Zfta-rela ependymoma Cancer neuroscience Developmental transcription factor 
UnknownSupratentorial non-RELA, ZFTA-fused ependymomas: a comprehensive phenotype genotype correlation highlighting the number of zinc fingers in ZFTA-NCOA1/2 fusions.
Not available
S-EPMC8362233 | biostudies-literature
GenomicsExtensive Vascular Remodeling Without Widespread Blood-Brain Barrier Disruption in a Murine Model of ZFTA-RELA Ependymoma
Extensive Vascular Remodeling Without Widespread Blood-Brain Barrier Disruption in a Murine Model of ZFTA-RELA Ependymoma
PRJNA1477906 | ENA
GenomicsZFTA-RELA Dictates Oncogenic Transcriptional Programs to Drive Aggressive Supratentorial Ependymoma
Over 60% of supratentorial (ST) ependymomas harbor a ZFTA-RELA (ZRfus) gene fusion (formerly C11orf95-RELA). To study the biology of ZRfus, we developed an autochthonous mouse tumor model using in utero electroporation (IUE) of the embryonic mouse brain. Integrative epigenomic and transcriptomic map...
ORGANISM(S): Mus musculus 
2021-03-29 | GSE161679 | GEO
GenomicsHistone serotonylation regulates ependymoma tumorigenesis through neurodevelopmental pathways [ChIP-Seq]
To profile H3K4me3Q5Ser (5HT-H3) distribution in mouse ZFTA-RELA ependymoma tumors Furthermore, we also sought to examine H3K27ac and H3K27me3 distribution in mouse ZFTA-RELA ependymoma versus ETV5 overexpressing tumors
ORGANISM(S): Mus musculus 
2024-06-03 | GSE246032 | GEO
TranscriptomicsHistone serotonylation regulates ependymoma tumorigenesis through neurodevelopmental pathways [RNA-seq]
To profile gene expression differences between mouse non-tumor cortex versus ZFTA-RELA ependymoma versus ETV5 overexpressing tumors Furthermore, we also sought to profile gene expression differences between ZFTA-RELA ependymoma versus NPY overexpressing tumor
ORGANISM(S): Mus musculus 
2024-06-03 | GSE246031 | GEO
UnknownA systems approach identifies MERTK as a therapeutic vulnerability in ZFTA-RELA-driven ependymomas.
Not available
S-EPMC12912970 | biostudies-literature
TranscriptomicsExtensive Vascular Remodeling Without Widespread Blood-Brain Barrier Disruption in a Murine Model of ZFTA-RELA Ependymoma
Background: ZFTA-RELA ependymoma (EPN) is the most common supratentorial pediatric EPN subtype and is associated with poor clinical outcomes. The blood-brain barrier (BBB) is a major obstacle to effective drug delivery into the brain. Brain tumors can exhibit substantial BBB heterogeneity, and the e...
ORGANISM(S): Mus musculus 
2026-07-29 | GSE335316 | GEO
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