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ProteomicspSILAC method coupled with two complementary digestion approaches reveals PRPF39 as a new E7070-dependent DCAF15 substrate
In this study, we used a novel strategy of pSILAC method coupled with two complementary digestion approaches to find potential substrates of E7070, and reveals PRPF39 as E7070-dependent DCAF15 substrate.
ORGANISM(S): Homo Sapiens 
2019-10-18 | PXD015892 |
ProteomicsProteomic and phosphoproteomic maps of lung squamous cell carcinoma from Chinese patients
Lung cancer in Chinese patients has distinct genomic features and lung squamous cell carcinoma (LUSC) has limited biomarkers for targeted therapy even though a lot of progress has been made in genomics research. Systematical research on LUSC at protein level will be beneficial to improve precision m...
ORGANISM(S): Homo Sapiens 
2020-05-16 | PXD019234 |
ProteomicsInegrative Proteomic Analysis Reveals the Cytaskeleton Regulation and Mtophagy Diference Between ischemicCardiomyopathy and Dilated Cardiomyopathy
Ischemic cardiomyopathy (ICM) and dilated cardiomyopathy (DCM) are the two primary etiologies of end-stage heart failure. However, there remains a dearth of comprehensive understanding the global perspective and the dynamics of the proteome and phosphoproteome in ICM and DCM, which hinders the profo...
ORGANISM(S): Homo Sapiens 
2025-06-18 | PXD065145 |
ProteomicsGlobal identification ofphospho-dependent SCF ubiquitin ligase substrate reveal a role of ERK-FBXO22-BAG3 axis in tumorigenesis
293T cells were cultured in SILAC medium. Heavy group was labeled with K6&R10. Light group was labeled with K0&R0. In light group, cells were treated with MLN4924. In heavy group, cells were treated with DMSO. Then cells were lysed, mixed and tryptic digested. Peptide mixture was subjected to phosph...
ORGANISM(S): Homo Sapiens 
2021-06-29 | PXD027020 |
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