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TranscriptomicsGene microarray of human embryonic stem cells, differentiated at three development stages, to investigate changes in the genomic transcripts associated with their glycome.
We are interested in investigating changes in both the glycome and transcriptome of human embryonic stem cells upon differentiation. We have chosen as a model system to differentiate human ES cells into neural spheres using a published protocol by Zhang, S.C. et al. (2001; Nat Biotech. 19: 1129-33)....
ORGANISM(S): Homo sapiens 
2011-09-05 | E-GEOD-31923 | biostudies-arrayexpress
UnknownAn asymmetric nautilus-like HflK/C assembly controls FtsH proteolysis of membrane proteins
Not available
S-SCDT-10_1038-S44318-025-00408-1 | biostudies-other
ModelsFang2011 - Genome-scale metabolic network of Burkholderia cenocepacia (iKF1028)
Fang2011 - Genome-scale metabolic network of Burkholderia cenocepacia (iKF1028) This model is described in the article: Exploring the metabolic network of the epidemic pathogen Burkholderia cenocepacia J2315 via genome-scale reconstruction. Fang K, Zhao H, Sun C, Lam CM, Chang...
2015-07-30 | MODEL1507180051 | BioModels
TranscriptomicsPemetrexed alters inflammatory profile in EA.hy 926 cells grown under low-folate conditions.
Pemetrexed is an antifolate drug used in the treatment of lung cancer. EA.hy 926 cells grown under low (Lo) and normal (Hi) folate conditions were treated with PMX. Microarray analysis was used to examine changes in gene expression due to PMX treatment. Hi and Lo cells were grown to confluence and m...
ORGANISM(S): Homo sapiens 
2012-10-03 | E-GEOD-31986 | biostudies-arrayexpress
GenomicsInduced Cdx2 binding in progenitor motor neurons and its effect on H3K27me3 chromatin domains [ChIP-Seq]
We aim to understand the role that Cdx2 plays in specifying the rostro-caudal identity of differentiating motor neurons. We find that expressing Cdx2 in combination with FGF signaling is sufficient to produce motor neurons with a more caudal identity. ChIP-seq analysis of Cdx2 finds that it binds ex...
ORGANISM(S): Mus musculus 
2013-07-04 | E-GEOD-39433 | biostudies-arrayexpress
TranscriptomicsWhite-to-brown metabolic conversion of human adipocytes by JAK inhibition
The rising incidence of obesity and related disorders such as diabetes and heart disease has focused considerable attention on the discovery of novel therapeutics. One promising approach has been to increase the number or activity of brown-like adipocytes in white adipose depots, as this has been...
ORGANISM(S): Homo sapiens 
2014-10-31 | E-GEOD-57896 | biostudies-arrayexpress
UnknownChromatin binding by HORMAD proteins regulates meiotic recombination initiation
Not available
S-SCDT-10_1038-S44318-024-00034-3 | biostudies-other
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