Sort   by:  
 Page size 
TranscriptomicsImpairment of Muscle Regeneration in Muscleblind-like 3 Isoform Knockout Mice
We have performed an RNA-seq experiment to identify expression and alternative splicing differences between WT and Mbnl3 isoform knockout mice E15 forelimbs. We have also identified and characterized transcriptome wide Mbnl3-binding sites in C2C12 cells and E15 forelimbs. 6 total samples were analyz...
ORGANISM(S): Mus musculus 
2013-05-18 | E-GEOD-46207 | biostudies-arrayexpress
TranscriptomicsMuscleblind-Like 2 mediated alternative splicing in the developing bain by mRNA sequencing
We have identified Mbnl2 mediated splicing events and mRNA expression regulation by comparing WT and Mbnl2 ?E2/?E2 mouse hippocampii using Affymetrix Mouse Exon Junction Array and mRNA sequencing. The splicing microarray data has already been submitted under GSE37908 which also includes a re-analys...
ORGANISM(S): Mus musculus 
2012-08-16 | E-GEOD-38497 | biostudies-arrayexpress
TranscriptomicsFMRP Associates with Polyribosomes
This SuperSeries is composed of the following subset Series: GSE26742: Determination of the relative abundance of mRNAs in a polyribosome-associated pool GSE26745: Comparison of total and polyribosome-associated mRNA levels in male Fmr1 KO mice and male WT littermates Refer to individual Series
ORGANISM(S): Mus musculus 
2011-07-20 | E-GEOD-26809 | biostudies-arrayexpress
TranscriptomicsIntegrative modeling defines the Nova splicing-regulatory network and its combinatorial controls: Exon array data
The control of RNA alternative splicing is critical for generating biological diversity. Despite emerging genome-wide technologies to study RNA complexity, reliable and comprehensive RNA-regulatory networks have not been defined. Here we used Bayesian networks to probabilistically model diverse data...
ORGANISM(S): Mus musculus 
2010-08-04 | E-GEOD-22115 | biostudies-arrayexpress
TranscriptomicsLoss of MBNL Leads to Disruption of Developmentally Regulated Alternative Polyadenylation in RNA-Mediated Disease
Mapping MBNL-regulated genome-wide alternative polyadenylation: We report that depletion of Mbnl proteins in mouse embryo fibroblasts (MEFs), DM mouse model quadriceps muscle, and DM-autopsy muscle tissue leads to mis-regulation of alternative polyadenylation We compared WT, Mbnl1/2KO, Mbnl1/2KO/3si...
ORGANISM(S): Homo sapiens 
2014-09-05 | E-GEOD-60487 | biostudies-arrayexpress
TranscriptomicsHITS-CLIP analysis of FMRP mRNA binding sites from P11-P25 mouse brain polysomes
FMRP loss-of-function causes Fragile X Syndrome (FXS) and autistic features. FMRP is a polyribosome-associated neuronal RNA-binding protein, suggesting that it plays a key role in regulating neuronal translation, but there has been little consensus regarding either its RNA targets or mechanism of a...
ORGANISM(S): Mus musculus 
2013-03-15 | E-GEOD-45148 | biostudies-arrayexpress
TranscriptomicsDetermination of the relative abundance of mRNAs in a polyribosome-associated pool
Polyribosomal fractions derived from P25 mice were the starting material for IPs of the FMRP protein and associated mRNA. Therefore we wanted to determine the relative abundance of all mRNAs in the starting pool for the IP as a denominator with which to compare the IPed material. [mRNA profiling]: ...
ORGANISM(S): Mus musculus 
2011-07-20 | E-GEOD-26742 | biostudies-arrayexpress
TranscriptomicsAnalysis of FoxA2 occupancy in mouse liver with endoderm ChIP-chip array
Understanding how silent genes can be competent for activation provides insight into development as well as cellular reprogramming and pathogenesis. We performed genomic location analysis of the pioneer transcription factor FoxA in the adult liver and found that about one-third of the FoxA bound si...
ORGANISM(S): Mus musculus 
2011-07-18 | E-GEOD-23551 | biostudies-arrayexpress
ProteomicsIntratracheal lipopolysaccharide (LPS)-induced acute lung injury (ALI) in Mouse Serum and lung DIA Proteomics Profiling
The aim of this project was to profile the proteome of mouse-derived serum in order to identify those that showed significant quantitative different proteins among ALI mice and controls.
ORGANISM(S): Mus Musculus 
2023-01-20 | PXD039618 |
TranscriptomicsIdentification of novel androgen-regulated pathways and mRNA isoforms through genome-wide exon-specific profiling of the LNCaP transcriptome
Androgens drive the onset and progression of prostate cancer (PCa) by modulating androgen receptor (AR) transcriptional activity. Although several microarray-based studies have identified androgen-regulated genes, here we identify in-parallel global androgen-dependent changes in both gene and alter...
ORGANISM(S): Homo sapiens 
2011-12-27 | E-GEOD-32875 | biostudies-arrayexpress
Sort   by:  
 Page size