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ProteomicsMulti-omics analysis of human peripheral blood reveals marked molecular profiling changes caused by one night of sleep deprivation
Sleep insufficiency is associated with various disorders (cardiovascular disease, neurodegenerative diseases, immunological disorders.) but the molecular bases for these associations are largely unknown. We used multiple omics techniques to examine changes in the blood of healthy male and female adu...
ORGANISM(S): Homo Sapiens 
2022-04-23 | PXD033402 |
ProteomicsCross-link of Drosophila P75 dimer
Use XL-MS to detect whether dP75 can form homodimer
ORGANISM(S): Drosophila Melanogaster 
2024-12-12 | PXD058799 |
ProteomicsA phosphorylation-dependent ubiquitination switch orchestrates nuclear immune reprogramming upon chitin perception
OsRLCK185 is a functional kinase, we then examined whether OsRLCK185 phosphorylates OsPUB20 using an in vitro kinase assay, OsRLCK185K108A served as a negative control. The results showed that GST-OsRLCK185, but not GST-OsRLCK185K108A, phosphorylates OsPUB20 in vitro. Using LC-MS/MS analysis after a...
ORGANISM(S): Oryza Sativa 
2026-01-29 | PXD073757 |
ProteomicsA phosphorylation-dependent ubiquitination switch orchestrates nuclear immune reprogramming
The nuclear localization of OsGF14f is crucial for blast resistance. To understand how OsGF14f functions in the nucleus to modulate blast resistance, we identified OsGF14f-interacting proteins by LC-MS/MS assays with OsGF14f-GFP plants. Among the candidate proteins, a nuclear-localized protein was O...
ORGANISM(S): Oryza Sativa 
2026-01-29 | PXD073756 |
ProteomicsCopper exposure aggravates motor phenotype via inhibiting mitophagy in SOD1G93A transgenic mice
Background Amyotrophic lateral sclerosis (ALS) is an age-dependent and incurable neurodegenerative disease. It is pathologically characterized by selective degeneration of motor neurons resulting in a catastrophic loss of motor function. Previous studies showed that excess copper (Cu) might have a r...
ORGANISM(S): Mus Musculus 
2023-01-29 | PXD039728 |
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