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Metabolomics13C glucose labelling studies using 2D NMR is a useful tool for determining ex vivo whole organ metabolism during hypothermic machine perfusion of kidneys
Background: The aim of this study is to determine the feasibility of using Nuclear Magnetic Resonance (NMR) tracer studies (13C-enriched glucose) to detect ex vivo de novo metabolism in the perfusion fluid and cortical tissue of porcine kidneys during hypothermic machine perfusion (HMP). Methods: Po...
2017-10-16 | MTBLS367 | MetaboLights
TranscriptomicsVariation in the Genomic islands of porcine enteropathogenic E. coli strains of serogroup O45 revealed by CGH and PCR.
Background: Members of E. coli serogroup O45 are porcine enteropathogenic E. coli (PEPEC) strains which cause post-weaning diarrhea and produce characteristic attaching and effacing (A/E) lesions. Most of O45 PEPEC strains possess the locus of enterocyte effacement (LEE), encoding the virulence fact...
ORGANISM(S): Escherichia coli 
2010-05-16 | E-GEOD-17036 | biostudies-arrayexpress
TranscriptomicsTranscriptome wt vs mdxR mutant in E. faecium E1162 grown in M1 with maltose
Comparative transcriptome analysis of E. faecium E1162 and its isogenic mdxR deletion mutant during growth in M1 with maltose in mid-exponential phase (A660 = 0.3)
ORGANISM(S): Enterococcus faecium 
2013-10-09 | E-MEXP-3759 | biostudies-arrayexpress
TranscriptomicsOverlapping and unique responses of E. coli to adverse conditions
In the present study we have determined the global gene expression and biomolecular composition in an Escherichia coli model strain exposed to ten adverse conditions (sodium chloride, ethanol, glycerol, two acids (hydrochloric acid and acetic acid), sodium hydroxide, heat (46°C) and cold (15°C) as...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2010-05-18 | E-GEOD-11041 | biostudies-arrayexpress
Transcriptomicszhang-arabidopsis-met1 vs ws
Comparison of met1 mutant with control
ORGANISM(S): Arabidopsis thaliana 
2012-02-19 | E-MEXP-3120 | biostudies-arrayexpress
ProteomicsMirror-image trypsin digestion and sequencing of D-proteins
The development of mirror-image biology systems and related applications is hindered by the lack of effective methods to sequence mirror-image (D-) proteins. Although natural-chirality (L-) proteins can be sequenced by bottom–up liquid chromatography–tandem mass spectrometry (LC–MS/MS), the sequenci...
ORGANISM(S): Escherichia coli 
2024-01-19 | PXD046228 | Pride
Total chemical synthesis D-trypsin D-protein sequencing Mirror-image biology Lc-ms/ms 
TranscriptomicsTranscription profiling of human prostate cancer cells, normal epithelial prostatic cells and stroma cells from patients in placebo, selenium, vitamin E or selenium and vitamin E treatment groups
85 radical prostatectomy specimens (where 16 samples are in Placebo group (PL), 15 are in Selenium group (SE), 25 are in Vitamin E group (VE) and 27 are in Vitamin E & Selenium group (VS.Treatment groups: l-selenomethionine, 400 ug + placebo (vitamin E); vitamin E, 400 IU + placebo (l-selenomethion...
ORGANISM(S): Homo sapiens 
2008-07-01 | E-MEXP-1327 | biostudies-arrayexpress
TranscriptomicsExpression data from the hearts of a mouse model of spontaneous myocardial infarction
Mice with homozygous null mutations in the HDL receptor (SR-BI) and apoE genes (SR-BI KO/apoE double KO (dKO) mice) spontaneously develop occlusive, atherosclerotic coronary artery disease (CAD) and die prematurely (50% mortality at 42 days of age) on standard chow diet feeding. Microarray analysis ...
ORGANISM(S): Mus musculus 
2013-09-01 | E-GEOD-49937 | biostudies-arrayexpress
TranscriptomicsTranscriptome wt vs mdxR mutant in E. faecium E1162 grown in BHI
Comparative transcriptome analysis of E. faecium E1162 and its isogenic mdxR deletion mutant during growth in BHI in mid-exponential phase (A660 = 0.3)
ORGANISM(S): Enterococcus faecium 
2013-10-09 | E-MEXP-3760 | biostudies-arrayexpress
TranscriptomicsA 6-month systems toxicology inhalation study in ApoE−/− mice demonstrates reduced cardiovascular effects of E-vapor aerosols compared to cigarette smoke.
Smoking cigarettes is harmful to the cardiovascular system. Considerable attention has been paid to the reduced harm potential of alternative nicotine-containing inhalable products such as e-cigarettes. We investigated the effects of E-vapor aerosols or cigarette smoke (CS) on atherosclerosis progre...
ORGANISM(S): Mus musculus 
2020-05-12 | E-MTAB-8578 | biostudies-arrayexpress
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