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GenomicsWhole Exome Sequencing of Chronic Lymphocytic Leukemia

The somatic genetic basis of chronic lymphocytic leukemia (CLL), a common and clinically heterogenous adult leukemia, remains poorly understood. Massively parallel sequencing technology now provides a method for systematic discovery of genetic alterations that underlie disease, and for uncovering...

phs000435.v1.p1 | EGA
TranscriptomicsGene expression analysis of non-cerebellar portion of Gb5-deficient mice brain
Gb5 is a divergent, evolutionarily-conserved, member of the heterotrimeric G protein b subunit family that is expressed principally in brain and neuronal tissue. Among Gb isoforms, Gb5 is unique in its ability to heterodimerize with members of the R7 subfamily of the regulator of G protein signalin...
ORGANISM(S): Mus musculus 
2011-09-12 | E-GEOD-29082 | biostudies-arrayexpress
TranscriptomicsCerebellar gene expression analysis of Gb5-deficient mice
Gb5 is a divergent, evolutionarily-conserved, member of the heterotrimeric G protein b subunit family that is expressed principally in brain and neuronal tissue. Among Gb isoforms, Gb5 is unique in its ability to heterodimerize with members of the R7 subfamily of the regulator of G protein signalin...
ORGANISM(S): Mus musculus 
2011-09-12 | E-GEOD-29081 | biostudies-arrayexpress
TranscriptomicsKnockout of heterotrimeric signaling G protein beta5 impaires brain development and causes severe neurologic dysfunction in mice
This SuperSeries is composed of the following subset Series: GSE29081: Cerebellar gene expression analysis of Gb5-deficient mice GSE29082: Gene expression analysis of non-cerebellar portion of Gb5-deficient mice brain Refer to individual Series
ORGANISM(S): Mus musculus 
2011-09-12 | E-GEOD-29083 | biostudies-arrayexpress
UnknownExtracellular Vesicle-Encapsulated Adeno-Associated Viruses for Therapeutic Gene Delivery to the Heart.
Not available
S-EPMC12462899 | biostudies-literature
UnknownGene editing reverses arrhythmia susceptibility in humanized PLN-R14del mice: modelling a European cardiomyopathy with global impact.
Not available
S-EPMC9732517 | biostudies-literature
TranscriptomicsmiR-155-5p regulates immune cell recruitment to the fetal lung after choriodecidual Group B Streptococcal infection
Mechanisms underlying in utero fetal lung injury remain poorly defined, and a greater understanding of pathways regulating these processes may lead to novel therapies that prevent lung injury before birth. MicroRNAs (miRNAs) are small non-coding, endogenous RNAs that regulate gene expression and hav...
ORGANISM(S): Macaca nemestrina 
2015-08-05 | E-GEOD-60628 | biostudies-arrayexpress
TranscriptomicsIsraeli acute paralysis virus – what we have learned about the virus since mysterious disappearance of the US honey bees known as Colony Collapse Disorder (CCD) in 2006
There were important gaps in our knowledge of Israeli acute paralysis virus (IAPV), when IAPV was tightly linked to bee Colony Collapse Disorder (CCD), the mysterious disease that, starting in 2006-2007, has been wiping out honey bees in the US. To fill in these gaps we studied the molecular basis ...
ORGANISM(S): Apis mellifera 
2014-04-08 | E-GEOD-46278 | biostudies-arrayexpress
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