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ProteomicsJEV Infected BV2 Cells with Proteomics
We sought to paint a panoramic picture of JEV-infected BV2 cells. High depth TMT labelling for quantitative proteomics was used to assess JEV infection with BV2 and compared immune response profiles at 6h, 12h, and 24h post-infection (hpi).According to gene ontology and KEGG enrichment analysis, imm...
ORGANISM(S): Mus musculus (Mouse) 
2022-09-09 | PXD033575 | Pride
Jev mouse proteomics 
ProteomicsPRM for JEV infected BV2 cells proteomics
Quantification of Differentially Expressed Proteins (DEPs) by PRM For the JEV-infected group, 15 upregulated DEPs were selected for validation by PRM. Protein extraction and tryptic digestion were performed following the same protocol used for the label-free quantitative proteomics experiment.
ORGANISM(S): Mus musculus (Mouse) 
2022-09-09 | PXD035938 | Pride
Prm Jev Bv2 
GenomicsDirect ChIP-bisulfite sequencing reveals a role of H3K27me3 mediating aberrant hypermethylation of promoter CpG islands in cancer cells (ChIP-BS)
The model describing that aberrant CpG island (CGI) methylation leads to transcription repression of tumor suppressor genes and thereby is implicated in tumor progression has been established in many cancers. However, recent studies indicated aberrantly hypermethylated genes in multiple cancers are ...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-43094 | biostudies-arrayexpress
GenomicsSorafenib inhibits epithelial-mesenchymal transition through an epigenetic-based mechanism in human lung epithelial cells
The epithelial to mesenchymal transition (EMT) has been well recognized for many decades as an essential early step in the progression of primary tumors towards metastases. Widespread epigenetic reprogramming of DNA and histone modifications tightly regulates gene expression and cellular activity du...
ORGANISM(S): Homo sapiens 
2012-10-11 | E-GEOD-41479 | biostudies-arrayexpress
TranscriptomicsDirect ChIP-bisulfite sequencing reveals a role of H3K27me3 mediating aberrant hypermethylation of promoter CpG islands in cancer cells (RNA-seq)
Aberrant DNA hypermethylation of CpG island (CGI) promoters are associated with transcriptional repression of many tumor suppressor genes and lead to tumor progression in many cancers. Most recently, one research group observed that aberrantly hypermethylated genes in multiple cancers are already re...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-43093 | biostudies-arrayexpress
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