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TranscriptomicsMiRNAs expression data from Atm++ and Atm-- mouse embryonic fibroblasts after DNA damage at various time point
Atm++ and Atm-- mouse embryonic fibroblasts were treated with DNA damaging agent neocarzinostatin (NCS), and cells were harvested at indicated time points for the microarray analyses of whole-genome miRNAs. To examine how miRNAs are regulated in the DNA damage response, we assessed the genome-wide m...
ORGANISM(S): Mus musculus 
2010-12-20 | E-TABM-1092 | biostudies-arrayexpress
MetabolomicsDifferent regions of synaptic vesicle membrane regulate VAMP2 conformation for the SNARE assembly
Vesicle associated membrane protein 2 (VAMP2/synaptobrevin2), a core SNARE protein residing on synaptic vesicles (SVs), forms helix bundles with syntaxin-1 and SNAP25 for the SNARE assembly. Prior to the SNARE assembly, the structure of VAMP2 is unclear. Here, by using in-cell NMR spectroscopy, we d...
2021-10-06 | MTBLS1503 | MetaboLights
UnknownlncRNA C2dat2 facilitates autophagy and apoptosis via the miR-30d-5p/DDIT4/mTOR axis in cerebral ischemia-reperfusion injury.
Not available
S-EPMC8109078 | biostudies-literature
UnknownA lincRNA-p21/miR-181 family feedback loop regulates microglial activation during systemic LPS- and MPTP- induced neuroinflammation.
Not available
S-EPMC6056543 | biostudies-literature
ProteomicsO-GlcNAcylation elevates topoisomerase IIα catalytic activity: a role in the chemotherapy resistance of breast cancer
DNA topoisomerase IIα (TOP2A) plays a vital role in replication and cell division by catalytically altering DNA topology. It is a prominent target for anticancer drugs. However, it is currently unknown whether TOP2A is O-GlcNAc-modified, and the mechanism by which interplay between TOP2A and O-GlcNA...
ORGANISM(S): Homo Sapiens 
2023-03-31 | PXD041284 |
UnknownNCKAP1 Disruptive Variants Lead to a Neurodevelopmental Disorder with Core Features of Autism.
Not available
S-EPMC7674997 | biostudies-literature
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