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TranscriptomicsPLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and glioma
A hallmark feature of glioblastoma (GBM) cells is its strong self-renewal potential and immature differentiation state -- stem cell-like properties which may contribute to the plasticity and intense therapeutic resistance of GBM. The molecular basis of the immature differentiation profile remains a...
ORGANISM(S): Mus musculus 
2010-06-23 | E-GEOD-21143 | biostudies-arrayexpress
TranscriptomicsKras is required for pancreatic tumor maintenance through regulation of hexosamine biosynthesis and the non-oxidative pentose phosphate pathway
The maintenance of advanced malignancies relies on continued activity of driver oncogenes, although their rate-limiting role is highly context-dependent with respect to tumor types and associated genetic alterations. Oncogenic Kras mutation is the signature event in human pancreatic ductal adenocar...
ORGANISM(S): Mus musculus 
2012-04-29 | E-GEOD-32277 | biostudies-arrayexpress
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