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UnknownEvolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates.
Pheromones are water-soluble chemicals released and sensed by individuals of the same species to elicit social and reproductive behaviors or physiological changes; they are perceived primarily by the vomeronasal organ (VNO) in terrestrial vertebrates. Humans and some related primates possess only ve...
S-EPMC166230 | biostudies-literature
UnknownWhy human disease-associated residues appear as the wild-type in other species: genome-scale structural evidence for the compensation hypothesis.
Many human-disease associated amino acid residues (DARs) appear as the wild-type in other species. This phenomenon is commonly explained by the presence of compensatory residues in these other species that alleviate the deleterious effects of the DARs. The general validity of this hypothesis, howeve...
S-EPMC4069617 | biostudies-literature
UnknownEvaluating Phylostratigraphic Evidence for Widespread De Novo Gene Birth in Genome Evolution.
The source of genetic novelty is an area of wide interest and intense investigation. Although gene duplication is conventionally thought to dominate the production of new genes, this view was recently challenged by a proposal of widespread de novo gene origination in eukaryotic evolution. Specifical...
S-EPMC5010002 | biostudies-literature
UnknownHuman long noncoding RNAs are substantially less folded than messenger RNAs.
Long noncoding RNAs (lncRNAs) do not code for proteins but function as RNAs. Because the functions of an RNA rely on either its sequence or secondary structure, lncRNAs should be folded at least as strongly as messenger RNAs (mRNAs), which serve as messengers for translation and are generally though...
S-EPMC4379403 | biostudies-literature
UnknownA simple method for estimating the strength of natural selection on overlapping genes.
Overlapping genes, where one DNA sequence codes for two proteins with different reading frames, are not uncommon in viruses and cellular organisms. Estimating the direction and strength of natural selection acting on overlapping genes is important for understanding their functionality, origin, evolu...
S-EPMC4316641 | biostudies-literature
UnknownAdaptive Genetic Robustness of Escherichia coli Metabolic Fluxes.
Genetic robustness refers to phenotypic invariance in the face of mutation and is a common characteristic of life, but its evolutionary origin is highly controversial. Genetic robustness could be an intrinsic property of biological systems, a result of direct natural selection, or a byproduct of sel...
S-EPMC5010001 | biostudies-literature
UnknownThe genotype-phenotype map of yeast complex traits: basic parameters and the role of natural selection.
Most phenotypic traits are controlled by many genes, but a global picture of the genotype-phenotype map (GPM) is lacking. For example, in no species do we know generally how many genes affect a trait and how large these effects are. It is also unclear to what extent GPMs are shaped by natural select...
S-EPMC4032135 | biostudies-literature
UnknownRepeatability of gene expression evolution in experimental environmental adaptation.
Assessing the relative roles of chance and necessity in evolution is of wide interest, but it requires evolving the same population under the same environment multiple times-a virtually impossible task in nature that has been repeatedly accomplished in the laboratory. Capitalizing on the transcripto...
S-EPMC12946262 | biostudies-literature
UnknownYeast mutation accumulation experiment supports elevated mutation rates at highly transcribed sites.
Not available
S-EPMC4191789 | biostudies-literature
UnknownAuthor Correction: The rate and molecular spectrum of mutation are selectively maintained in yeast.
Not available
S-EPMC10073079 | biostudies-literature
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