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UnknownRNA structure profiling at single-cell resolution reveals new determinants of cell identity.
RNA structure is critical for multiple steps in gene regulation. However, how the structures of transcripts differ both within and between individual cells is unknown. Here we develop a SHAPE-inspired method called single-cell structure probing of RNA transcripts that enables simultaneous determinat...
S-EPMC10927541 | biostudies-literature
UnknownAsynchronous warming and δ18O evolution of deep Atlantic water masses during the last deglaciation.
The large-scale reorganization of deep ocean circulation in the Atlantic involving changes in North Atlantic Deep Water (NADW) and Antarctic Bottom Water (AABW) played a critical role in regulating hemispheric and global climate during the last deglaciation. However, changes in the relative contribu...
S-EPMC5651742 | biostudies-literature
UnknownSmall molecule inhibitor targets OmpV to treat pandemic Vibrio cholerae infection.
Cholera, a severe diarrhoeal illness caused by Vibrio cholerae (V. cholerae), poses a significant threat to public health worldwide. The emergence of multidrug-resistant V. cholerae strains underscores the urgent need for preventive and therapeutic interventions. In this study, we elucidate the role...
S-EPMC12823570 | biostudies-literature
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