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This study presents a longitudinal multi-omics analysis of COVID-19 convalescents with respiratory sequelae, spanning 6–36 months post-infection. The integrating proteomic and metabolomic profiling uncovers persistent molecular alterations, impaired diffusing capacity for carbon monoxide, and propos...
ORGANISM(S): Homo Sapiens 
2025-02-23 | PXD061113 |
Objective: This study aimed to investigate plasma exosome profiling of IgG4-RD and its potential role in B cell differentiation and tissue damage. Methods: One hundred untreated IgG4-RD patients and 135 sex, age matched healthy controls (HCs) were enrolled in this study. A combination of liquid chro...
ORGANISM(S): Homo Sapiens 
Cancer cells undergo transcriptional reprogramming to drive tumor progression and metastasis. Here, we identified the transcriptional complex, NELF (Negative elongation factor), as an important regulator of this process. Using cancer cell lines and patient-derived tumor organoids, we demonstrated th...
ORGANISM(S): Homo Sapiens (human) 
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